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4k0n
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of human CLIC1 C24A mutant== | |
| - | === | + | <StructureSection load='4k0n' size='340' side='right' caption='[[4k0n]], [[Resolution|resolution]] 1.25Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4k0n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K0N FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jzq|4jzq]], [[4k0g|4k0g]], [[4k1d|4k1d]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLIC1, CLIC1 G6 NCC27, G6, NCC27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k0n RCSB], [http://www.ebi.ac.uk/pdbsum/4k0n PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref> | [[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref> | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human]] | |
| - | <references | + | [[Category: Curmi, P M.G]] |
| - | [[Category: Curmi, P M.G | + | [[Category: Duff, A P]] |
| - | [[Category: Duff, A P | + | [[Category: Harrop, S J]] |
| - | [[Category: Harrop, S J | + | [[Category: Phang, J M]] |
| - | [[Category: Phang, J M | + | [[Category: Wilk, K E]] |
| - | [[Category: Wilk, K E | + | |
[[Category: Chloride ion channel]] | [[Category: Chloride ion channel]] | ||
[[Category: Clic]] | [[Category: Clic]] | ||
[[Category: Glutathione-s-transferase fold]] | [[Category: Glutathione-s-transferase fold]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 12:32, 25 December 2014
Crystal structure of human CLIC1 C24A mutant
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