4pw6

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'''Unreleased structure'''
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==structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II==
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<StructureSection load='4pw6' size='340' side='right' caption='[[4pw6]], [[Resolution|resolution]] 3.79&Aring;' scene=''>
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The entry 4pw6 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4pw6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PW6 OCA]. <br>
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Authors: Zhou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., Xu. R.M.
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pw5|4pw5]]</td></tr>
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Description: structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pw6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pw6 PDBsum]</span></td></tr>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.
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== Function ==
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[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.<ref>PMID:12176013</ref> <ref>PMID:15178429</ref> <ref>PMID:14741369</ref> <ref>PMID:15361834</ref> <ref>PMID:21952639</ref> <ref>PMID:23404503</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Wang, M.]]
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[[Category: Wong, J.]]
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[[Category: Xiong, J.]]
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[[Category: Xu, R M.]]
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[[Category: Yang, N.]]
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[[Category: Zhou, T.]]
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[[Category: Zhu, B.]]
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[[Category: 5hmc binding]]
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[[Category: 5hmc-containing dna]]
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[[Category: Hydroxymethylation]]
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[[Category: Ligase-dna complex]]
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[[Category: Nuclear]]
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[[Category: Sra]]

Revision as of 08:24, 7 May 2014

structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II

4pw6, resolution 3.79Å

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