4pzg

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'''Unreleased structure'''
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==Crystal structure of human sorting nexin 10 (SNX10)==
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<StructureSection load='4pzg' size='340' side='right' caption='[[4pzg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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The entry 4pzg is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4pzg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZG FirstGlance]. <br>
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Authors: Xu, T., Xu, J., Wang, Q., Liu, J.
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4on3|4on3]]</td></tr>
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Description: Crystal structure of human sorting nexin 10 (SNX10)
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pzg RCSB], [http://www.ebi.ac.uk/pdbsum/4pzg PDBsum]</span></td></tr>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN]] Autosomal recessive malignant osteopetrosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22499339</ref> <ref>PMID:23123320</ref> <ref>PMID:23280965</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN]] Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.<ref>PMID:17012226</ref> <ref>PMID:21844891</ref> <ref>PMID:22499339</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Liu, J.]]
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[[Category: Wang, Q.]]
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[[Category: Xu, J.]]
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[[Category: Xu, T.]]
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[[Category: Phox-homology domain]]
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[[Category: Protein transport]]
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[[Category: Sorting nexin]]

Revision as of 10:48, 24 September 2014

Crystal structure of human sorting nexin 10 (SNX10)

4pzg, resolution 2.80Å

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