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3w63
From Proteopedia
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| - | + | ==MamM-CTD 215-293== | |
| - | === | + | <StructureSection load='3w63' size='340' side='right' caption='[[3w63]], [[Resolution|resolution]] 1.90Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3w63]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnetospirillum_gryphiswaldense_msr-1 Magnetospirillum gryphiswaldense msr-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W63 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w5x|3w5x]], [[3w5y|3w5y]], [[3w5z|3w5z]], [[3w60|3w60]], [[3w61|3w61]], [[3w62|3w62]], [[3w64|3w64]], [[3w65|3w65]], [[3w66|3w66]], [[3w8p|3w8p]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mamM, mgI491, MGR_4095 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=431944 Magnetospirillum gryphiswaldense MSR-1])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w63 RCSB], [http://www.ebi.ac.uk/pdbsum/3w63 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cation diffusion facilitators (CDF) are part of a highly conserved protein family that maintains cellular divalent cation homeostasis in all domains of life. CDF's were shown to be involved in several human diseases, such as Type-II diabetes and neurodegenerative diseases. In this work, we employed a multi-disciplinary approach to study the activation mechanism of the CDF protein family. For this we used MamM, one of the main ion transporters of magnetosomes - bacterial organelles that enable magnetotactic bacteria to orientate along geomagnetic fields. Our results reveal that the cytosolic domain of MamM forms a stable dimer that undergoes distinct conformational changes upon divalent cation binding. MamM conformational change is associated with three metal binding sites that were identified and characterized. Altogether, our results provide a novel auto-regulation mode of action model in which the cytosolic domain's conformational changes upon ligand binding allows the priming of the CDF into its transport mode. | ||
| - | + | Cation diffusion facilitators transport initiation and regulation is mediated by cation induced conformational changes of the cytoplasmic domain.,Zeytuni N, Uebe R, Maes M, Davidov G, Baram M, Raschdorf O, Nadav-Tsubery M, Kolusheva S, Bitton R, Goobes G, Friedler A, Miller Y, Schuler D, Zarivach R PLoS One. 2014 Mar 21;9(3):e92141. doi: 10.1371/journal.pone.0092141. eCollection, 2014. PMID:24658343<ref>PMID:24658343</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Davidov, G | + | == References == |
| - | [[Category: Zarivach, R | + | <references/> |
| - | [[Category: Zeytuni, N | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Magnetospirillum gryphiswaldense msr-1]] | ||
| + | [[Category: Davidov, G]] | ||
| + | [[Category: Zarivach, R]] | ||
| + | [[Category: Zeytuni, N]] | ||
[[Category: Divalent cation transport]] | [[Category: Divalent cation transport]] | ||
[[Category: Metal ion transport]] | [[Category: Metal ion transport]] | ||
[[Category: Metal transport]] | [[Category: Metal transport]] | ||
Revision as of 09:47, 4 January 2015
MamM-CTD 215-293
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