Retinoid X receptor

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'''Retinoid X receptor''' (RXR) is a nuclear receptor activated by 9-cis retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RAR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD). There are 3 classes of RXR: α, β and γ. For additional details on RXR-α see [[RA Mediated T-reg Differentiation]].
'''Retinoid X receptor''' (RXR) is a nuclear receptor activated by 9-cis retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RAR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD). There are 3 classes of RXR: α, β and γ. For additional details on RXR-α see [[RA Mediated T-reg Differentiation]].
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</StructureSection>
==3D structures of retinoid X receptor==
==3D structures of retinoid X receptor==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Retinoid X receptor α===
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*Retinoid X receptor α
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[[3nsp]], [[1lbd]], [[1g1u]] - hRXR LBD – human<br />
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**[[3nsp]], [[1lbd]], [[1g1u]] - hRXR LBD – human<br />
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[[1rxr]] – hRXR DBD (mutant) – NMR<br />
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**[[1rxr]] – hRXR DBD (mutant) – NMR<br />
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[[2q60]] – RXR LBD – ''Polyandrocarpa misakiensis''<br />
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**[[2q60]] – RXR LBD – ''Polyandrocarpa misakiensis''<br />
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[[1by4]] – hRXR + DNA<br />
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**[[1by4]] – hRXR + DNA<br />
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[[1g5y]] - hRXR LBD + retinoid<br />
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**[[1g5y]] - hRXR LBD + retinoid<br />
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[[1dkf]] – mRXR LBD + mRAR LBD – mouse<br />
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**[[1dkf]] – mRXR LBD + mRAR LBD – mouse<br />
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[[1dsz]] - hRXR LBD + hRAR LBD + DNA<br />
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**[[1dsz]] - hRXR LBD + hRAR LBD + DNA<br />
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[[1fby]] - hRXR LBD + 9-cis retinoic acid<br />
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**[[1fby]] - hRXR LBD + 9-cis retinoic acid<br />
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[[3nsq]] - hRXR LBD + antagonist<br />
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**[[3nsq]] - hRXR LBD + antagonist<br />
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[[3a9e]] - hRXR LBD + hRAR LBD + coactivator peptide<br />
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**[[3a9e]] - hRXR LBD + hRAR LBD + coactivator peptide<br />
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[[3fug]] - hRXR LBD + coactivator peptide<br />
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**[[3fug]] - hRXR LBD + coactivator peptide<br />
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[[3fc6]] – hRXR LBD + NR1H3 protein<br />
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**[[3fc6]] – hRXR LBD + NR1H3 protein<br />
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[[3r29]] - hRXR LBD + corepressor peptide SMRT2<br />
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**[[3r29]] - hRXR LBD + corepressor peptide SMRT2<br />
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[[3r2a]] - hRXR LBD + corepressor peptide SMRT2 + antagonist<br />
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**[[3r2a]] - hRXR LBD + corepressor peptide SMRT2 + antagonist<br />
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[[3h0a]], [[1fm6]], [[1fm9]], [[1k74]] - hRXR LBD + PPAR-γ + 9-cis retinoic acid + coactivator peptide<br />
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**[[3h0a]], [[1fm6]], [[1fm9]], [[1k74]] - hRXR LBD + PPAR-γ + 9-cis retinoic acid + coactivator peptide<br />
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[[1rdt]] - hRXR LBD + PPAR-γ + coactivator peptide<br />
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**[[1rdt]] - hRXR LBD + PPAR-γ + coactivator peptide<br />
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[[3dzu]], [[3dzy]], [[3e00]] - hRXR LBD + PPAR-γ + 9-cis retinoic acid + coactivator peptide + DNA<br />
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**[[3dzu]], [[3dzy]], [[3e00]] - hRXR LBD + PPAR-γ + 9-cis retinoic acid + coactivator peptide + DNA<br />
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[[3oap]] - hRXR LBD + 9-cis retinoic acid + coactivator peptide<br />
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**[[3oap]] - hRXR LBD + 9-cis retinoic acid + coactivator peptide<br />
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[[3uvv]] - hRXR LBD + 9-cis retinoic acid + thyronine + thyroid hormone receptor α<br />
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**[[3uvv]] - hRXR LBD + 9-cis retinoic acid + thyronine + thyroid hormone receptor α<br />
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[[3ozj]] - hRXR LBD + bigelovin + coactivator peptide<br />
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**[[3ozj]] - hRXR LBD + bigelovin + coactivator peptide<br />
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[[3pcu]] - hRXR LBD + rutamarin + coactivator peptide<br />
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**[[3pcu]] - hRXR LBD + rutamarin + coactivator peptide<br />
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[[2zxz]], [[2zy0]], [[3r5m]], [[1mzn]], [[1mv9]], [[1mvc]], [[4k4j]], [[4k6i]], [[4m8e]], [[4m8h]] - hRXR LBD + agonist + coactivator peptide<br />
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**[[2zxz]], [[2zy0]], [[3r5m]], [[1mzn]], [[1mv9]], [[1mvc]], [[4k4j]], [[4k6i]], [[4m8e]], [[4m8h]] - hRXR LBD + agonist + coactivator peptide<br />
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[[2acl]] - hRXR LBD + agonist + oxysterols receptor α<br />
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**[[2acl]] - hRXR LBD + agonist + oxysterols receptor α<br />
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[[3fal]] - hRXR LBD + modulator + oxysterols receptor α + 9-cis retinoic acid<br />
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**[[3fal]] - hRXR LBD + modulator + oxysterols receptor α + 9-cis retinoic acid<br />
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[[3kwy]] - hRXR LBD + triphenyltin + coactivator peptide<br />
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**[[3kwy]] - hRXR LBD + triphenyltin + coactivator peptide<br />
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[[3e94]] - hRXR LBD + tributylin + coactivator peptide<br />
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**[[3e94]] - hRXR LBD + tributylin + coactivator peptide<br />
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[[2p1t]], [[2p1u]], [[2p1v]] - hRXR LBD + retinoid + coactivator peptide<br />
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**[[2p1t]], [[2p1u]], [[2p1v]] - hRXR LBD + retinoid + coactivator peptide<br />
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[[1xls]] - hRXR LBD (mutant) + orphan nuclear receptor NR1I3 + coactivator peptide<br />
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**[[1xls]] - hRXR LBD (mutant) + orphan nuclear receptor NR1I3 + coactivator peptide<br />
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[[1xv9]] - hRXR LBD + orphan nuclear receptor NR1I3 + pregnane + coactivator peptide<br />
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**[[1xv9]] - hRXR LBD + orphan nuclear receptor NR1I3 + pregnane + coactivator peptide<br />
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[[1xvp]] - hRXR LBD + orphan nuclear receptor NR1I3 + CITCO + coactivator peptide<br />
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**[[1xvp]] - hRXR LBD + orphan nuclear receptor NR1I3 + CITCO + coactivator peptide<br />
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[[4j5w]] - hRXR LBD + orphan nuclear receptor PXR<br />
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**[[4j5w]] - hRXR LBD + orphan nuclear receptor PXR<br />
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[[4j5x]] - hRXR LBD + orphan nuclear receptor PXR + phosphonic acid derivative<br />
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**[[4j5x]] - hRXR LBD + orphan nuclear receptor PXR + phosphonic acid derivative<br />
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[[1r0n]], [[1ynw]] - hRXR DBD + DR3 response element + vitamin D3 receptor <br />
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**[[1r0n]], [[1ynw]] - hRXR DBD + DR3 response element + vitamin D3 receptor <br />
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[[4nqa]] - hRXR DBD + DR4 response element + liver X nuclear receptor + coactivator peptide <br />
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**[[4nqa]] - hRXR DBD + DR4 response element + liver X nuclear receptor + coactivator peptide <br />
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===Retinoid X receptor β===
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*Retinoid X receptor β
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[[1xdk]] - mRXR LBD + mRAR LBD + thyroid receptor associated protein<br />
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**[[1xdk]] - mRXR LBD + mRAR LBD + thyroid receptor associated protein<br />
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[[1uhl]] - hRXR LBD + oxysterols receptor α + coactivator peptide<br />
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**[[1uhl]] - hRXR LBD + oxysterols receptor α + coactivator peptide<br />
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[[1h9u]] – hRXR LBD + agonist
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**[[1h9u]] – hRXR LBD + agonist
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===Retinoid X receptor γ===
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*Retinoid X receptor γ
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[[2gl8]] – hRXR LBD
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**[[2gl8]] – hRXR LBD
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:52, 7 December 2014

Structure of human retinoid X receptor ligand-binding domain tetramer complex with retinoid (PDB entry 1g5y)

Drag the structure with the mouse to rotate

3D structures of retinoid X receptor

Updated on 07-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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