4cn9
From Proteopedia
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| - | + | ==structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus with zinc occupied MIDAS motif== | |
| - | + | <StructureSection load='4cn9' size='340' side='right' caption='[[4cn9]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4cn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mytga Mytga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CN9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cn8|4cn8]], [[4cnb|4cnb]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cn9 RCSB], [http://www.ebi.ac.uk/pdbsum/4cn9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Blue mussels adhere to surfaces by the byssus, a holdfast structure composed of individual threads representing a collagen fibre reinforced composite. Here, we present the crystal structure and function of one of its matrix proteins, the proximal thread matrix protein 1, which is present in the proximal section of the byssus. The structure reveals two von Willebrand factor type A domains linked by a two-beta-stranded linker yielding a novel structural arrangement. In vitro, the protein binds heterologous collagens with high affinity and affects collagen assembly, morphology and arrangement of its fibrils. By providing charged surface clusters as well as insufficiently coordinated metal ions, the proximal thread matrix protein 1 might interconnect other byssal proteins and thereby contribute to the integrity of the byssal threads in vivo. Moreover, the protein could be used for adjusting the mechanical properties of collagen materials, a function likely important in the natural byssus. | ||
| - | + | Structural and functional features of a collagen-binding matrix protein from the mussel byssus.,Suhre MH, Gertz M, Steegborn C, Scheibel T Nat Commun. 2014 Feb 26;5:3392. doi: 10.1038/ncomms4392. PMID:24569701<ref>PMID:24569701</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mytga]] | [[Category: Mytga]] | ||
| - | [[Category: Gertz, M | + | [[Category: Gertz, M]] |
| - | [[Category: Scheibel, T | + | [[Category: Scheibel, T]] |
| - | [[Category: Steegborn, C | + | [[Category: Steegborn, C]] |
| - | [[Category: Suhre, M H | + | [[Category: Suhre, M H]] |
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 14:29, 4 January 2015
structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus with zinc occupied MIDAS motif
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