3wtp
From Proteopedia
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| - | ''' | + | ==Crystal Structure of the heterotypic nucleosome containing human CENP-A and H3.3== |
| + | <StructureSection load='3wtp' size='340' side='right' caption='[[3wtp]], [[Resolution|resolution]] 2.67Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3wtp]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WTP FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wtp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wtp RCSB], [http://www.ebi.ac.uk/pdbsum/3wtp PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. In the present study, we report the crystal structure of the heterotypic CENP-A/H3.3 particle and reveal its "hybrid structure", in which the physical characteristics of CENP-A and H3.3 are conserved independently within the same particle. The CENP-A/H3.3 nucleosome forms an unexpectedly stable structure as compared to the CENP-A nucleosome, and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A overexpressing cells. | ||
| - | + | Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.,Arimura Y, Shirayama K, Horikoshi N, Fujita R, Taguchi H, Kagawa W, Fukagawa T, Almouzni G, Kurumizaka H Sci Rep. 2014 Nov 19;4:7115. doi: 10.1038/srep07115. PMID:25408271<ref>PMID:25408271</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Almouzni, G]] | ||
| + | [[Category: Arimura, Y]] | ||
| + | [[Category: Fujita, R]] | ||
| + | [[Category: Fukagawa, T]] | ||
| + | [[Category: Horikoshi, N]] | ||
| + | [[Category: Kagawa, W]] | ||
| + | [[Category: Kurumizaka, H]] | ||
| + | [[Category: Shirayama, K]] | ||
| + | [[Category: Chromatin formation]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Histone fold]] | ||
Revision as of 09:22, 3 December 2014
Crystal Structure of the heterotypic nucleosome containing human CENP-A and H3.3
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