1t5m

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{{STRUCTURE_1t5m| PDB=1t5m | SCENE= }}
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==Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin==
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===Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin===
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<StructureSection load='1t5m' size='340' side='right' caption='[[1t5m]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_15271353}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t5m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T5M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xt7|1xt7]], [[1t5n|1t5n]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t5m RCSB], [http://www.ebi.ac.uk/pdbsum/1t5m PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Daptomycin is a cyclic anionic lipopeptide antibiotic recently approved for the treatment of complicated skin infections (Cubicin). Its function is dependent on calcium (as Ca2+). Circular dichroism spectroscopy indicated that daptomycin experienced two structural transitions: a transition upon interaction of daptomycin with Ca2+, and a further transition upon interaction with Ca2+ and the bacterial acidic phospholipid, phosphatidyl glycerol. The Ca2+-dependent insertion of daptomycin into model membranes promoted mild and more pronounced perturbations as assessed by the increase of lipid flip-flop and membrane leakage, respectively. The NMR structure of daptomycin indicated that Ca2+ induced a conformational change in daptomycin that increased its amphipathicity. These results are consistent with the hypothesis that the association of Ca2+ with daptomycin permits it to interact with bacterial membranes with effects that are similar to those of the cationic antimicrobial peptides.
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==About this Structure==
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Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin.,Jung D, Rozek A, Okon M, Hancock RE Chem Biol. 2004 Jul;11(7):949-57. PMID:15271353<ref>PMID:15271353</ref>
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[[1t5m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5M OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:015271353</ref><references group="xtra"/><references/>
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</div>
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[[Category: Hancock, R E.]]
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== References ==
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[[Category: Jung, D.]]
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<references/>
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[[Category: Okon, M.]]
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__TOC__
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[[Category: Rozek, A.]]
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</StructureSection>
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[[Category: Hancock, R E]]
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[[Category: Jung, D]]
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[[Category: Okon, M]]
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[[Category: Rozek, A]]
[[Category: Antibiotic]]
[[Category: Antibiotic]]
[[Category: Calcium-dependent]]
[[Category: Calcium-dependent]]

Revision as of 05:42, 22 December 2014

Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin

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