2cdf

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{{STRUCTURE_2cdf| PDB=2cdf | SCENE= }}
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==STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)==
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===STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)===
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<StructureSection load='2cdf' size='340' side='right' caption='[[2cdf]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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{{ABSTRACT_PUBMED_16520393}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b88|1b88]], [[1bwm|1bwm]], [[1h5b|1h5b]], [[1hxm|1hxm]], [[1ktk|1ktk]], [[1l0y|1l0y]], [[1nfd|1nfd]], [[1tvd|1tvd]], [[2axh|2axh]], [[2axj|2axj]], [[2cde|2cde]], [[2cdg|2cdg]], [[1ao7|1ao7]], [[1qrn|1qrn]], [[1qse|1qse]], [[1qsf|1qsf]], [[1bd2|1bd2]], [[1lp9|1lp9]], [[1mi5|1mi5]], [[2bnq|2bnq]], [[2bnr|2bnr]], [[2bnu|2bnu]], [[1kgc|1kgc]], [[1fo0|1fo0]], [[1kj2|1kj2]], [[1nam|1nam]], [[2ckb|2ckb]], [[1g6r|1g6r]], [[1mwa|1mwa]], [[1kb5|1kb5]], [[1tcr|1tcr]], [[1fyt|1fyt]], [[1j8h|1j8h]], [[1d9k|1d9k]], [[1ymm|1ymm]], [[1ypz|1ypz]], [[1zt4|1zt4]], [[1z5l|1z5l]], [[1zhn|1zhn]], [[2akr|2akr]], [[1cd1|1cd1]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [http://www.ebi.ac.uk/pdbsum/2cdf PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Invariant human TCR Valpha24-Jalpha18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-alpha-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-alpha-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha chains. The results were similar to those previously reported for MHC-peptide-specific TCRs, illustrating the versatility of the TCR platform. Docking TCR and CD1d-alpha-GalCer structures provided plausible insights into their interaction. The model supports a diagonal orientation of TCR on CD1d and suggests that complementarity determining region (CDR)3alpha, CDR3beta, and CDR1beta interact with ligands presented by CD1d, whereas CDR2beta binds to the CD1d alpha1 helix. This docking provides an explanation for the dominant usage of Vbeta11 and Vbeta8.2 chains by human and mouse iNKT cells, respectively, for recognition of CD1d-alpha-GalCer.
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==About this Structure==
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Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.,Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:16520393<ref>PMID:16520393</ref>
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[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:016520393</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cerundolo, V.]]
[[Category: Cerundolo, V.]]

Revision as of 10:08, 3 October 2014

STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)

2cdf, resolution 2.25Å

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