2jxu

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(New page: 200px<br /><applet load="2jxu" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jxu" /> '''NMR solution structure of KP-TerB, a telluri...)
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[[Image:2jxu.jpg|left|200px]]<br /><applet load="2jxu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2jxu.jpg|left|200px]]
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caption="2jxu" />
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'''NMR solution structure of KP-TerB, a tellurite resistance protein from Klebsiella pneumoniae'''<br />
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{{Structure
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|PDB= 2jxu |SIZE=350|CAPTION= <scene name='initialview01'>2jxu</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= terB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])
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}}
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'''NMR solution structure of KP-TerB, a tellurite resistance protein from Klebsiella pneumoniae'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2JXU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXU OCA].
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2JXU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXU OCA].
==Reference==
==Reference==
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NMR solution structure of KP-TerB, a tellurite-resistance protein from Klebsiella pneumoniae., Chiang SK, Lou YC, Chen C, Protein Sci. 2008 Feb 27;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18305192 18305192]
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NMR solution structure of KP-TerB, a tellurite-resistance protein from Klebsiella pneumoniae., Chiang SK, Lou YC, Chen C, Protein Sci. 2008 Feb 27;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18305192 18305192]
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: unknown function]]
[[Category: unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Mar 14 09:31:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:45:48 2008''

Revision as of 15:45, 20 March 2008


PDB ID 2jxu

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Gene: terB (Klebsiella pneumoniae)
Coordinates: save as pdb, mmCIF, xml



NMR solution structure of KP-TerB, a tellurite resistance protein from Klebsiella pneumoniae


Overview

Klebsiella pneumoniae (KP), a Gram-negative bacterium, is a common cause of hospital-acquired bacterial infections worldwide. Tellurium (Te) compounds, although relatively rare in the environment, have a long history as antimicrobial and therapeutic agents. In bacteria, tellurite (TeO(3) (-2)) resistance is conferred by the ter (Te(r)) operon (terZABCDEF). Here, on the basis of 2593 restraints derived from NMR analysis, we report the NMR structure of TerB protein (151 amino acids) of KP (KP-TerB), which is mainly composed of seven alpha-helices and a 3(10) helix, with helices II to V apparently forming a four-helix bundle. The ensemble of 20 NMR structures was well-defined, with a RMSD of 0.32 +/- 0.06 A for backbone atoms and 1.11 +/- 0.07 A for heavy atoms, respectively. A unique property of the KP-TerB structure is that the positively and negatively charged clusters are formed by the N-terminal positively and C-terminal negatively charged residues, respectively. To the best of our knowledge, the protein sequence and structures of KP-TerB are unique.

About this Structure

2JXU is a Single protein structure of sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA.

Reference

NMR solution structure of KP-TerB, a tellurite-resistance protein from Klebsiella pneumoniae., Chiang SK, Lou YC, Chen C, Protein Sci. 2008 Feb 27;. PMID:18305192

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