2qzt

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(New page: 200px<br /><applet load="2qzt" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qzt, resolution 1.700&Aring;" /> '''Crystal Structure o...)
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[[Image:2qzt.jpg|left|200px]]<br /><applet load="2qzt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2qzt.jpg|left|200px]]
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caption="2qzt, resolution 1.700&Aring;" />
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'''Crystal Structure of Sterol Carrier Protein 2 Like 2 (SCP2-L2) from Aedes Aegypti'''<br />
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{{Structure
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|PDB= 2qzt |SIZE=350|CAPTION= <scene name='initialview01'>2qzt</scene>, resolution 1.700&Aring;
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|SITE= <scene name='pdbsite=AC1:Plm+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Plm+Binding+Site+For+Residue+B+301'>AC2</scene> and <scene name='pdbsite=AC3:Plm+Binding+Site+For+Residue+A+302'>AC3</scene>
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|LIGAND= <scene name='pdbligand=PLM:PALMITIC ACID'>PLM</scene>
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|ACTIVITY=
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|GENE= Sterol Carrier Protein 2 Like 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 Aedes aegypti])
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}}
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'''Crystal Structure of Sterol Carrier Protein 2 Like 2 (SCP2-L2) from Aedes Aegypti'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2QZT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti] with <scene name='pdbligand=PLM:'>PLM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Plm+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Plm+Binding+Site+For+Residue+B+301'>AC2</scene> and <scene name='pdbsite=AC3:Plm+Binding+Site+For+Residue+A+302'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZT OCA].
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2QZT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZT OCA].
==Reference==
==Reference==
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Three-dimensional structure/function analysis of SCP-2-like2 reveals differences among SCP-2 family members., Dyer DH, Wessely V, Forest KT, Lan Q, J Lipid Res. 2008 Mar;49(3):644-53. Epub 2007 Dec 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18084051 18084051]
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Three-dimensional structure/function analysis of SCP-2-like2 reveals differences among SCP-2 family members., Dyer DH, Wessely V, Forest KT, Lan Q, J Lipid Res. 2008 Mar;49(3):644-53. Epub 2007 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18084051 18084051]
[[Category: Aedes aegypti]]
[[Category: Aedes aegypti]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: sterol carrier]]
[[Category: sterol carrier]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Mar 14 09:35:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:31:13 2008''

Revision as of 16:31, 20 March 2008

Image:2qzt.jpg


PDB ID 2qzt

Drag the structure with the mouse to rotate
, resolution 1.700Å
Sites: , and
Ligands:
Gene: Sterol Carrier Protein 2 Like 2 (Aedes aegypti)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Sterol Carrier Protein 2 Like 2 (SCP2-L2) from Aedes Aegypti


Overview

Mosquito sterol carrier protein-2 (AeSCP-2) and sterol carrier protein-2-like2 (AeSCP-2L2) are members of the SCP-2 protein family with similar expression profiles in the mosquito life cycle. In an effort to understand how lipids can be transported by different SCP-2 proteins, the three-dimensional crystal structure of AeSCP-2L2 was solved at 1.7 A resolution. AeSCP-2L2 forms a dimer and binds three fatty acids, one of which resides in a position within the internal cavity at a right angle to the others. This first report of ligand-bound dimerized protein in the SCP-2 protein family indicates that the family has a much more divergent mode of interaction with ligands than previously reported. The potential function of AeSCP-2L2 was investigated via in vivo incorporation of [(3)H]cholesterol and [(3)H]palmitic acid. Overexpression of AeSCP-2L2 in mosquito cells leads to an increased uptake of free fatty acid, whereas knockdown of AeSCP-2L2 in adult females decreases the accumulation of free fatty acid in the fat body from a blood meal. In contrast, overexpression or knockdown of AeSCP-2L2 has no effect on cholesterol uptake. Our results suggest that the main function of AeSCP-2L2 is as a general intracellular fatty acid carrier, as opposed to having a dedicated role in cholesterol transport.

About this Structure

2QZT is a Single protein structure of sequence from Aedes aegypti. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure/function analysis of SCP-2-like2 reveals differences among SCP-2 family members., Dyer DH, Wessely V, Forest KT, Lan Q, J Lipid Res. 2008 Mar;49(3):644-53. Epub 2007 Dec 15. PMID:18084051

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