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4q6h

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m (Protected "4q6h" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==CFTR Associated Ligand (CAL) bound to last 6 residues of CFTR (decameric peptide: iCAL36VQDTRL)==
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<StructureSection load='4q6h' size='340' side='right' caption='[[4q6h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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The entry 4q6h is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4q6h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6H OCA]. <br>
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Authors: Amacher, J.F., Madden, D.R.
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k75|4k75]]</td></tr>
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Description: CFTR Associated Ligand (CAL) bound to last 6 residues of CFTR (decameric peptide: iCAL36VQDTRL)
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6h RCSB], [http://www.ebi.ac.uk/pdbsum/4q6h PDBsum]</span></td></tr>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Amacher, J F.]]
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[[Category: Madden, D R.]]
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[[Category: Cystic fibrosis transmembrane conductance regulator]]
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[[Category: Pdz-peptide complex]]
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[[Category: Transport protein]]

Revision as of 07:29, 14 May 2014

CFTR Associated Ligand (CAL) bound to last 6 residues of CFTR (decameric peptide: iCAL36VQDTRL)

4q6h, resolution 1.90Å

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