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2l8i
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
[[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA]. <br> | [[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA]. <br> | ||
| + | <b>[[Non-Standard_Residue|NonStd Res:]]</b> <scene name='pdbligand=2L8:'>2L8</scene><br> | ||
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | ||
| + | <b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l8i RCSB], [http://www.ebi.ac.uk/pdbsum/2l8i PDBsum]</span><br> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA. | Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA. | ||
Revision as of 10:00, 30 April 2014
A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex
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