2r9y
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2r9y.jpg|left|200px]] | + | [[Image:2r9y.jpg|left|200px]] |
| - | + | ||
| - | '''Structure of antiplasmin''' | + | {{Structure |
| + | |PDB= 2r9y |SIZE=350|CAPTION= <scene name='initialview01'>2r9y</scene>, resolution 2.65Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= Serpinf2, Pli ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of antiplasmin''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2R9Y is a [ | + | 2R9Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9Y OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin., Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB, Blood. 2008 Feb 15;111(4):2049-52. Epub 2007 Dec 6. PMID:[http:// | + | X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin., Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB, Blood. 2008 Feb 15;111(4):2049-52. Epub 2007 Dec 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18063751 18063751] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 27: | Line 36: | ||
[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:33:56 2008'' |
Revision as of 16:33, 20 March 2008
| |||||||
| , resolution 2.65Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | Serpinf2, Pli (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of antiplasmin
Overview
The serpin alpha(2)-antiplasmin (SERPINF2) is the principal inhibitor of plasmin and inhibits fibrinolysis. Accordingly, alpha(2)-antiplasmin deficiency in humans results in uncontrolled fibrinolysis and a bleeding disorder. alpha(2)-antiplasmin is an unusual serpin, in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. To understand how this may happen, we have determined the 2.65A X-ray crystal structure of an N-terminal truncated murine alpha(2)-antiplasmin. The structure reveals that part of the C-terminal sequence is tightly associated with the body of the serpin. This would be anticipated to position the flexible plasmin-binding portion of the C-terminus in close proximity to the serpin Reactive Center Loop where it may act as a template to accelerate serpin/protease interactions.
About this Structure
2R9Y is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin., Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB, Blood. 2008 Feb 15;111(4):2049-52. Epub 2007 Dec 6. PMID:18063751
Page seeded by OCA on Thu Mar 20 18:33:56 2008
