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JMS/Sandbox21

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<StructureSection load='3fhi' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='3fhi' size='340' side='right' caption='Caption for this structure' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<scene name='58/583419/Pka_reg/1'>The PKA catalytic unit (C) crystalized with the regulatory unit (R)</scene>, pdb structure [[3fhi]]<ref>PMID:15692043</ref>, is shown with small lobe in gray, large lobe in tan and regulatory unit in light blue. The residues from exon 1 (labeled) <scene name='58/583419/Pka_reg/2'>are distant</scene> from the residues which bind to the regulatory unit R (shown in ball and stick). The last three residues from exon 1 (residues # 13-15) are the only translated amino acids from first exon of pkaca that were well-crystalized in this structure. These three residues are <scene name='58/583419/Pka_reg/3'>distant from PKI-interacting residues (with yellow halos)</scene> - a second regulator/inhibitor of 'C', as well. This is also obvious from the pdb structure for the <scene name='58/583419/Pka_pki/1'>crystal of C bound to PKI</scene>, [[1atp]]<ref>PMID:15299527</ref>.
+
<scene name='58/583419/Pka_reg/1'>The PKA catalytic unit (C) crystalized with the regulatory unit (R)</scene>, pdb structure [[3fhi]]<ref>PMID:15692043</ref>, is shown with small lobe in gray, large lobe in tan and regulatory unit in light blue.
 +
 
 +
There is a significant distance <scene name='58/583419/Pka_reg/2'>from the residues from ''exon 1'' (labeled) to the residues which bind</scene> the regulatory unit R (shown in ball and stick). The last three residues from exon 1 (residues # 13-15) are the only translated amino acids from first exon of pkaca that were well-structured in this crystal structure.
 +
 
 +
These three residues are also <scene name='58/583419/Pka_reg/3'>distant from PKI-interacting residues (with yellow halos)</scene> - a second regulator/inhibitor of 'C', as well.
 +
This is also obvious from the pdb structure for the <scene name='58/583419/Pka_pki/1'>crystal of C bound to PKI (purple)</scene>, [[1atp]]<ref>PMID:15299527</ref>.
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 14:26, 1 May 2014

PKA and Regulators

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Kim C, Xuong NH, Taylor SS. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science. 2005 Feb 4;307(5710):690-6. PMID:15692043 doi:307/5710/690
  2. ↑ Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, Sowadski JM. 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):362-5. PMID:15299527 doi:10.1107/S0907444993000423

Proteopedia Page Contributors and Editors (what is this?)

Joseph M. Steinberger

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