Serine palmitoyltransferase

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{{STRUCTURE_3a2b| PDB=3a2b | SIZE=400| SCENE= |right|CAPTION=Monomer of the dimeric prokaryotic serine palmitoyltransferase complex with serine and cofactor pyridoxal phosphate [[3a2b]] }}
{{STRUCTURE_3a2b| PDB=3a2b | SIZE=400| SCENE= |right|CAPTION=Monomer of the dimeric prokaryotic serine palmitoyltransferase complex with serine and cofactor pyridoxal phosphate [[3a2b]] }}
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== Function ==
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'''Serine palmitoyltransferase''' (SPT) catalyzes the conversion of palmitoyl-CoA and serine to CoA and dehydro-sphinganine. This reaction is part of sphingosine biosynthesis. Pyridoxal phosphate (PLP) is a cofactor in the reaction. The prokaryotic SPT is a soluble homodimer while the eukaryotic one is heterodimeric and is anchored in the endoplasmic reticulum<ref>PMID:12782147</ref>.
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'''Serine palmitoyltransferase''' (SPT) catalyzes the conversion of palmitoyl-CoA and serine to CoA and dehydro-sphinganine. This reaction is part of sphingosine biosynthesis. Pyridoxal phosphate is a cofactor in the reaction. The prokaryotic SPT is a soluble homodimer while the eukaryotic one is heterodimeric and is anchored in the endoplasmic reticulum.
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==3D structures of serine palmitoyltransferase==
==3D structures of serine palmitoyltransferase==
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[[3a2b]] – SPT + pyridoxal phosphate + serine – ''Sphingobacterium multivorum''<br />
[[3a2b]] – SPT + pyridoxal phosphate + serine – ''Sphingobacterium multivorum''<br />
[[2x8u]] - SwSPT + pyridoxal derivative – ''Sphingomonas wittichii''<br />
[[2x8u]] - SwSPT + pyridoxal derivative – ''Sphingomonas wittichii''<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:02, 25 August 2016

Template:STRUCTURE 3a2b

Function

Serine palmitoyltransferase (SPT) catalyzes the conversion of palmitoyl-CoA and serine to CoA and dehydro-sphinganine. This reaction is part of sphingosine biosynthesis. Pyridoxal phosphate (PLP) is a cofactor in the reaction. The prokaryotic SPT is a soluble homodimer while the eukaryotic one is heterodimeric and is anchored in the endoplasmic reticulum[1].

3D structures of serine palmitoyltransferase

Updated on 25-August-2016

2jg2 – PpSPT + aldimine – Pseudomonas paucimobilis
2jgt – PpSPT
2w8j - SpSPT + aldimine – Sphingomonas paucimobilis
2w8t, 2w8u, 2w8v, 2w8w - SpSPT (mutant) + aldimine
4bmk - SpSPT (mutant) + myriocin + PLP
2xbn – SpSPT + pyridoxamine phosphate
3a2b – SPT + pyridoxal phosphate + serine – Sphingobacterium multivorum
2x8u - SwSPT + pyridoxal derivative – Sphingomonas wittichii

References

  1. ↑ Hanada K. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30. PMID:12782147

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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