4cbu
From Proteopedia
(Difference between revisions)
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<StructureSection load='4cbu' size='340' side='right' caption='[[4cbu]], [[Resolution|resolution]] 1.30Å' scene=''> | <StructureSection load='4cbu' size='340' side='right' caption='[[4cbu]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cbu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBU OCA]. <br> | + | <table><tr><td colspan='2'>[[4cbu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CBU FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbw|4cbw]], [[4cbx|4cbx]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbw|4cbw]], [[4cbx|4cbx]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cbu RCSB], [http://www.ebi.ac.uk/pdbsum/4cbu PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/ACT1_PLAFX ACT1_PLAFX]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility. [[http://www.uniprot.org/uniprot/GELS_MOUSE GELS_MOUSE]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural differences explain diverse functions of Plasmodium actins.,Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Siden-Kiamos I, Sachse C, Kursula I PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091., eCollection 2014 Apr. PMID:24743229<ref>PMID:24743229</ref> | Structural differences explain diverse functions of Plasmodium actins.,Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Siden-Kiamos I, Sachse C, Kursula I PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091., eCollection 2014 Apr. PMID:24743229<ref>PMID:24743229</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Andreadaki, M | + | [[Category: Lk3 transgenic mice]] |
| - | [[Category: Bhargav, S P | + | [[Category: Plafa]] |
| - | [[Category: Desfosses, A | + | [[Category: Andreadaki, M]] |
| - | [[Category: Frischknecht, F | + | [[Category: Bhargav, S P]] |
| - | [[Category: Ignatev, A | + | [[Category: Desfosses, A]] |
| - | [[Category: Kumpula, E P | + | [[Category: Frischknecht, F]] |
| - | [[Category: Kursula, I | + | [[Category: Ignatev, A]] |
| - | [[Category: Lepper, S | + | [[Category: Kumpula, E P]] |
| - | [[Category: Martinez, S Munico | + | [[Category: Kursula, I]] |
| - | [[Category: Sachse, C | + | [[Category: Lepper, S]] |
| - | [[Category: Siden-Kiamos, I | + | [[Category: Martinez, S Munico]] |
| - | [[Category: Vahokoski, J | + | [[Category: Sachse, C]] |
| + | [[Category: Siden-Kiamos, I]] | ||
| + | [[Category: Vahokoski, J]] | ||
[[Category: Malaria]] | [[Category: Malaria]] | ||
[[Category: Motility]] | [[Category: Motility]] | ||
[[Category: Motor protein]] | [[Category: Motor protein]] | ||
[[Category: Parasite]] | [[Category: Parasite]] | ||
Revision as of 07:23, 25 December 2014
Crystal structure of Plasmodium falciparum actin I
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