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4mrh
From Proteopedia
(Difference between revisions)
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<StructureSection load='4mrh' size='340' side='right' caption='[[4mrh]], [[Resolution|resolution]] 1.12Å' scene=''> | <StructureSection load='4mrh' size='340' side='right' caption='[[4mrh]], [[Resolution|resolution]] 1.12Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mrh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRH OCA]. <br> | + | <table><tr><td colspan='2'>[[4mrh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRH FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CQ:4-CHLORO-5-METHYLBENZENE-1,2-DIAMINE'>2CQ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CQ:4-CHLORO-5-METHYLBENZENE-1,2-DIAMINE'>2CQ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrd|4mrd]], [[4mre|4mre]], [[4mrf|4mrf]], [[4mrg|4mrg]], [[4np2|4np2]], [[4np3|4np3]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrd|4mrd]], [[4mre|4mre]], [[4mrf|4mrf]], [[4mrg|4mrg]], [[4np2|4np2]], [[4np3|4np3]]</td></tr> |
| - | <tr><td class="sblockLbl"><b> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd44, Cd44 Ly-24, Ly-24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mrh RCSB], [http://www.ebi.ac.uk/pdbsum/4mrh PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mrh RCSB], [http://www.ebi.ac.uk/pdbsum/4mrh PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors.,Liu LK, Finzel BC J Med Chem. 2014 Mar 27;57(6):2714-25. doi: 10.1021/jm5000276. Epub 2014 Mar 7. PMID:24606063<ref>PMID:24606063</ref> | Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors.,Liu LK, Finzel BC J Med Chem. 2014 Mar 27;57(6):2714-25. doi: 10.1021/jm5000276. Epub 2014 Mar 7. PMID:24606063<ref>PMID:24606063</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Finzel, B | + | [[Category: Lk3 transgenic mice]] |
| - | [[Category: Liu, L K | + | [[Category: Finzel, B]] |
| + | [[Category: Liu, L K]] | ||
[[Category: Cell adhesion-inhibitor complex]] | [[Category: Cell adhesion-inhibitor complex]] | ||
[[Category: Cell receptor]] | [[Category: Cell receptor]] | ||
Revision as of 17:30, 25 December 2014
Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule
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