2llk
From Proteopedia
(Difference between revisions)
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<StructureSection load='2llk' size='340' side='right' caption='[[2llk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2llk' size='340' side='right' caption='[[2llk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2llk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLK OCA]. <br> | + | <table><tr><td colspan='2'>[[2llk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LLK FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DMTF1, DMP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DMTF1, DMP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2llk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2llk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2llk RCSB], [http://www.ebi.ac.uk/pdbsum/2llk PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/DMTF1_HUMAN DMTF1_HUMAN]] Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.<ref>PMID:12917399</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C | + | [[Category: Arrowsmith, C]] |
| - | [[Category: Bellanda, M | + | [[Category: Bellanda, M]] |
| - | [[Category: Garcia, M | + | [[Category: Garcia, M]] |
| - | [[Category: Houliston, S | + | [[Category: Houliston, S]] |
| - | [[Category: Lemak, A | + | [[Category: Lemak, A]] |
| - | [[Category: Min, J | + | [[Category: Min, J]] |
| - | [[Category: Montecchio, M | + | [[Category: Montecchio, M]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | [[Category: Xu, C]] | |
| - | [[Category: Xu, C | + | [[Category: Yee, A]] |
| - | [[Category: Yee, A | + | |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Helix bundle]] | [[Category: Helix bundle]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 19:08, 24 December 2014
Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin-D-binding transcription factor 1 (hDMP1), Northeast Structural Genomics Consortium (NESG) target ID hr8011a
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Categories: Homo sapiens | Arrowsmith, C | Bellanda, M | Garcia, M | Houliston, S | Lemak, A | Min, J | Montecchio, M | Montelione, G T | Structural genomic | Xu, C | Yee, A | Cell cycle | Helix bundle | Nesg | Sgc | Transcription
