2kxc
From Proteopedia
(Difference between revisions)
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<StructureSection load='2kxc' size='340' side='right' caption='[[2kxc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2kxc' size='340' side='right' caption='[[2kxc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kxc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXC OCA]. <br> | + | <table><tr><td colspan='2'>[[2kxc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KXC FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAIAP2L1, IRTKS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAIAP2L1, IRTKS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxc RCSB], [http://www.ebi.ac.uk/pdbsum/2kxc PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/BI2L1_HUMAN BI2L1_HUMAN]] May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:17430976</ref> <ref>PMID:19366662</ref> <ref>PMID:22921828</ref> [[http://www.uniprot.org/uniprot/Q8X2D5_ECO57 Q8X2D5_ECO57]] Required for efficient pedestal formation in host epithelial cells during infection. Acts as an intermediate between Tir (via host BAIAP2) and host WASL/N-WASP. Directly binds and activates WASL/N-WASP, which stimulates actin polymerization and leads to the formation of actin pedestals at the sites of bacterial adhesion (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.,Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21743-8. Epub 2010 Nov 22. PMID:21098279<ref>PMID:21098279</ref> | Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.,Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21743-8. Epub 2010 Nov 22. PMID:21098279<ref>PMID:21098279</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aitio, O | + | [[Category: Aitio, O]] |
| - | [[Category: Hellman, M | + | [[Category: Hellman, M]] |
| - | [[Category: Kazlauskas, A | + | [[Category: Kazlauskas, A]] |
| - | [[Category: Leong, J M | + | [[Category: Leong, J M]] |
| - | [[Category: Permi, P | + | [[Category: Permi, P]] |
| - | [[Category: Saksela, K | + | [[Category: Saksela, K]] |
| - | [[Category: Vingadassalom, D F | + | [[Category: Vingadassalom, D F]] |
[[Category: Complex structure]] | [[Category: Complex structure]] | ||
[[Category: Espfu]] | [[Category: Espfu]] | ||
[[Category: Irtks-sh3]] | [[Category: Irtks-sh3]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 20:23, 24 December 2014
1H, 13C, and 15N Chemical Shift Assignments for IRTKS-SH3 and EspFu-R47 complex
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