User:Yunlong Zhao/Sandbox 1
From Proteopedia
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==Introduction== | ==Introduction== | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | + | Antithrombin and thrombin interactions play an important role in multiple functions. Interestingly, an heparin or polysaccharides can regulate the function of antithrombin to different signaling. <ref>DOI 10.1021/bi034524y</ref> | |
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| - | == | + | == Heparin Binding site on antithrombin == |
| - | + | Green scene 1 will be a antithrombin specific site for binding heparin | |
| + | Green scene 2 will be the complex with heparin | ||
| - | == | + | == The mechanism of heparin regulating antithrombin thrombin interaction == |
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| + | Green scene 1 will be the interface between AT and thrombin | ||
| + | Green scene 2 will be the the interface structure plus heparin | ||
| - | == Structural highlights == | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 17:54, 5 May 2014
Introduction
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References
- ↑ Johnson DJ, Huntington JA. Crystal structure of antithrombin in a heparin-bound intermediate state. Biochemistry. 2003 Jul 29;42(29):8712-9. PMID:12873131 doi:10.1021/bi034524y
