4o1m
From Proteopedia
(Difference between revisions)
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<StructureSection load='4o1m' size='340' side='right' caption='[[4o1m]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4o1m' size='340' side='right' caption='[[4o1m]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4o1m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1M OCA]. <br> | + | <table><tr><td colspan='2'>[[4o1m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O1M FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2o2s|2o2s]], [[3nj8|3nj8]], [[2ptg|2ptg]], [[2o2y|2o2y]], [[2o50|2o50]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2o2s|2o2s]], [[3nj8|3nj8]], [[2ptg|2ptg]], [[2o2y|2o2y]], [[2o50|2o50]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Enoyl reductase, ENR, TGVEG_000410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Enoyl reductase, ENR, TGVEG_000410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o1m RCSB], [http://www.ebi.ac.uk/pdbsum/4o1m PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o1m RCSB], [http://www.ebi.ac.uk/pdbsum/4o1m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.,Wilkinson C, McPhillie MJ, Zhou Y, Woods S, Afanador GA, Rawson S, Khaliq F, Prigge ST, Roberts CW, Rice DW, McLeod R, Fishwick CW, Muench SP Bioorg Med Chem Lett. 2014 Feb 1;24(3):911-6. doi: 10.1016/j.bmcl.2013.12.066., Epub 2013 Dec 22. PMID:24398298<ref>PMID:24398298</ref> | The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.,Wilkinson C, McPhillie MJ, Zhou Y, Woods S, Afanador GA, Rawson S, Khaliq F, Prigge ST, Roberts CW, Rice DW, McLeod R, Fishwick CW, Muench SP Bioorg Med Chem Lett. 2014 Feb 1;24(3):911-6. doi: 10.1016/j.bmcl.2013.12.066., Epub 2013 Dec 22. PMID:24398298<ref>PMID:24398298</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Toxgo]] | [[Category: Toxgo]] | ||
| - | [[Category: Muench, S P | + | [[Category: Muench, S P]] |
| - | [[Category: Prigge, S T | + | [[Category: Prigge, S T]] |
| - | [[Category: Rice, D W | + | [[Category: Rice, D W]] |
| - | [[Category: Wilkinson, C | + | [[Category: Wilkinson, C]] |
[[Category: Enoyl acyl carrier protein reductase]] | [[Category: Enoyl acyl carrier protein reductase]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Rossmann fold]] | [[Category: Rossmann fold]] | ||
Revision as of 09:23, 5 January 2015
Toxoplasma gondii Enoyl acyl carrier protein reductase
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