4crt
From Proteopedia
(Difference between revisions)
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<StructureSection load='4crt' size='340' side='right' caption='[[4crt]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4crt' size='340' side='right' caption='[[4crt]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4crt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRT OCA]. <br> | + | <table><tr><td colspan='2'>[[4crt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRT FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASS:(E)-N-METHYL-N-[[1-METHYL-5-[3-[1-(PHENYLMETHYL)PIPERIDIN-4-YL]PROPOXY]INDOL-2-YL]METHYL]PROP-1-EN-1-AMINE'>ASS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASS:(E)-N-METHYL-N-[[1-METHYL-5-[3-[1-(PHENYLMETHYL)PIPERIDIN-4-YL]PROPOXY]INDOL-2-YL]METHYL]PROP-1-EN-1-AMINE'>ASS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4crt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4crt RCSB], [http://www.ebi.ac.uk/pdbsum/4crt PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4crt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4crt RCSB], [http://www.ebi.ac.uk/pdbsum/4crt PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.,Esteban G, Allan J, Samadi A, Mattevi A, Unzeta M, Marco-Contelles J, Binda C, Ramsay RR Biochim Biophys Acta. 2014 Mar 16. pii: S1570-9639(14)00056-9. doi:, 10.1016/j.bbapap.2014.03.006. PMID:24642166<ref>PMID:24642166</ref> | Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.,Esteban G, Allan J, Samadi A, Mattevi A, Unzeta M, Marco-Contelles J, Binda C, Ramsay RR Biochim Biophys Acta. 2014 Mar 16. pii: S1570-9639(14)00056-9. doi:, 10.1016/j.bbapap.2014.03.006. PMID:24642166<ref>PMID:24642166</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Monoamine oxidase]] | [[Category: Monoamine oxidase]] | ||
| - | [[Category: Allan, J | + | [[Category: Allan, J]] |
| - | [[Category: Binda, C | + | [[Category: Binda, C]] |
| - | [[Category: Esteban, G | + | [[Category: Esteban, G]] |
| - | [[Category: Marco-Contelles, J | + | [[Category: Marco-Contelles, J]] |
| - | [[Category: Mattevi, A | + | [[Category: Mattevi, A]] |
| - | [[Category: Ramsay, R R | + | [[Category: Ramsay, R R]] |
| - | [[Category: Samadi, A | + | [[Category: Samadi, A]] |
| - | [[Category: Unzeta, M | + | [[Category: Unzeta, M]] |
[[Category: Alzheimer's disease]] | [[Category: Alzheimer's disease]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
Revision as of 13:01, 25 December 2014
Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234
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Categories: Human | Monoamine oxidase | Allan, J | Binda, C | Esteban, G | Marco-Contelles, J | Mattevi, A | Ramsay, R R | Samadi, A | Unzeta, M | Alzheimer's disease | Drug design | Enzyme | Flavin | Oxidoreductase
