4igm
From Proteopedia
(Difference between revisions)
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<StructureSection load='4igm' size='340' side='right' caption='[[4igm]], [[Resolution|resolution]] 2.39Å' scene=''> | <StructureSection load='4igm' size='340' side='right' caption='[[4igm]], [[Resolution|resolution]] 2.39Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4igm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGM OCA]. <br> | + | <table><tr><td colspan='2'>[[4igm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IGM FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminocarboxymuconate-semialdehyde_decarboxylase Aminocarboxymuconate-semialdehyde decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.45 4.1.1.45] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4igm RCSB], [http://www.ebi.ac.uk/pdbsum/4igm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4igm RCSB], [http://www.ebi.ac.uk/pdbsum/4igm PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACMSD_HUMAN ACMSD_HUMAN]] Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.<ref>PMID:19843166</ref> <ref>PMID:12140278</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Aminocarboxymuconate-semialdehyde decarboxylase]] | [[Category: Aminocarboxymuconate-semialdehyde decarboxylase]] | ||
| - | [[Category: Liu, A | + | [[Category: Liu, A]] |
| - | [[Category: Liu, F | + | [[Category: Liu, F]] |
[[Category: Kynurenine pathway]] | [[Category: Kynurenine pathway]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
Revision as of 12:20, 25 December 2014
2.39 Angstrom X-ray Crystal structure of human ACMSD
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