2vsg
From Proteopedia
(Difference between revisions)
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<StructureSection load='2vsg' size='340' side='right' caption='[[2vsg]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='2vsg' size='340' side='right' caption='[[2vsg]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2vsg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSG OCA]. <br> | + | <table><tr><td colspan='2'>[[2vsg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VSG FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vsg|1vsg]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vsg|1vsg]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vsg RCSB], [http://www.ebi.ac.uk/pdbsum/2vsg PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/VSI4_TRYBB VSI4_TRYBB]] VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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A structural motif in the variant surface glycoproteins of Trypanosoma brucei.,Blum ML, Down JA, Gurnett AM, Carrington M, Turner MJ, Wiley DC Nature. 1993 Apr 15;362(6421):603-9. PMID:8464512<ref>PMID:8464512</ref> | A structural motif in the variant surface glycoproteins of Trypanosoma brucei.,Blum ML, Down JA, Gurnett AM, Carrington M, Turner MJ, Wiley DC Nature. 1993 Apr 15;362(6421):603-9. PMID:8464512<ref>PMID:8464512</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Trypanosoma brucei]] | [[Category: Trypanosoma brucei]] | ||
| - | [[Category: Blum, M L | + | [[Category: Blum, M L]] |
| - | [[Category: Down, J A | + | [[Category: Down, J A]] |
| - | [[Category: Freymann, D M | + | [[Category: Freymann, D M]] |
| - | [[Category: Metcalf, P | + | [[Category: Metcalf, P]] |
| - | [[Category: Wiley, D C | + | [[Category: Wiley, D C]] |
[[Category: Antigenic variation]] | [[Category: Antigenic variation]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Trypanosome]] | [[Category: Trypanosome]] | ||
[[Category: Vsg]] | [[Category: Vsg]] | ||
Revision as of 16:15, 25 December 2014
A Structural Motif in the Variant Surface Glycoproteins of Trypanosoma Brucei
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