User:Jaakko Itkonen

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 13: Line 13:
==Introduction==
==Introduction==
-
Ciliary neutrophic factor (CNTF) is a nerve growth factor belonging to the IL-6 family
+
Ciliary neutrophic factor (CNTF) is a nerve growth factor belonging to the interleukin-6 family
of neuropoietic cytokines.
of neuropoietic cytokines.
Other members of this family include leukaemie inhibitory factor (LIF), IL-6, IL-11 and
Other members of this family include leukaemie inhibitory factor (LIF), IL-6, IL-11 and
oncostatin M (Wang 2012).
oncostatin M (Wang 2012).
-
CNTF is a roughly 22.7 kDa protein consisting of a single
+
 
-
peptide chain of 200 amino acid residues.
+
 
-
Like many other cytokines, CNTF is folded
+
-
into a bundle of four anti-parallel α-helices (A-D), where helices A-B and C-D are connected
+
-
by two cross-over loops and helices B-C by one short loop.
+
<scene name='58/584309/Cntf/1'>TextToBeDisplayed</scene>
<scene name='58/584309/Cntf/1'>TextToBeDisplayed</scene>
Line 30: Line 27:
Overview
Overview
 +
CNTF is a roughly 22.7 kDa protein consisting of a single
 +
polypeptide chain of 200 amino acid residues.
 +
Like with many other cytokines, the tertiary structure of CNTF
 +
consists of four anti-parallel α-helices (A-D), where helices A-B and C-D are connected
 +
by two cross-over loops and helices B-C by one short loop.
Line 35: Line 37:
==References==
==References==
 +
 +
Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GCA, Gascan H ja Gauchat J-F: Expression of biologically active mouse ciliary neurotrophic factor (CNTF) and soluble CNTFRα in Eschericia coli and characterization of their functional specificities. Eur Cytokine Netw 15: 255-262 (2004).
 +
 +
Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM ja Wen R: CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS One 5: 1-7 (2010).
 +
 +
Li Y, Wen R, Banzon T, Maminishkis A ja Miller SS: CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One 6: 1-7 (2011).
 +
 +
McDonald NQ, Panayotatos N ja Hendrickson WA: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J 14: 2689-2699 (1995).
 +
 +
Richardson PM: Ciliary neurotrophic factor: A review. Pharmac Ther 63: 187-198 (1994).
 +
 +
Sieving PA, Caruse RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR ja Bush RA: Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. PNAS 103: 3896-3901 (2006).
 +
 +
Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD ja Wiegand SJ: The ciliary neurotrophic factor and its receptor, CNTFRα. Pharm Acta Helv 74: 265-272 (2000).
 +
 +
Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM ja Sieving PA: Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 26: 13523-13530 (2006).
 +
 +
Wen R, Tao W, Li Y ja Sieving PA: CNTF and retina. Prog Retin Eye Res 31: 136-151 (2012).

Revision as of 12:00, 7 May 2014

  • Full Real Name: Jaakko Matias Itkonen
  • Position: Student
  • Institution (NO ABBREVIATIONS): University of Helsinki, Faculty Of Pharmacy, Division of Pharmaceutical Biosciences
  • City, State/Province, Country: Helsinki, Finland
  • Field of Expertise or Study: Pharmacy

Contents

Introduction

Ciliary neutrophic factor (CNTF) is a nerve growth factor belonging to the interleukin-6 family of neuropoietic cytokines. Other members of this family include leukaemie inhibitory factor (LIF), IL-6, IL-11 and oncostatin M (Wang 2012).


Fig. 1 X-ray structure of a truncated form of hCNTF (2-187)

Structure

Overview

CNTF is a roughly 22.7 kDa protein consisting of a single polypeptide chain of 200 amino acid residues. Like with many other cytokines, the tertiary structure of CNTF consists of four anti-parallel α-helices (A-D), where helices A-B and C-D are connected by two cross-over loops and helices B-C by one short loop.


Disease

References

Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GCA, Gascan H ja Gauchat J-F: Expression of biologically active mouse ciliary neurotrophic factor (CNTF) and soluble CNTFRα in Eschericia coli and characterization of their functional specificities. Eur Cytokine Netw 15: 255-262 (2004).

Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM ja Wen R: CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS One 5: 1-7 (2010).

Li Y, Wen R, Banzon T, Maminishkis A ja Miller SS: CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One 6: 1-7 (2011).

McDonald NQ, Panayotatos N ja Hendrickson WA: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J 14: 2689-2699 (1995).

Richardson PM: Ciliary neurotrophic factor: A review. Pharmac Ther 63: 187-198 (1994).

Sieving PA, Caruse RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR ja Bush RA: Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. PNAS 103: 3896-3901 (2006).

Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD ja Wiegand SJ: The ciliary neurotrophic factor and its receptor, CNTFRα. Pharm Acta Helv 74: 265-272 (2000).

Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM ja Sieving PA: Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 26: 13523-13530 (2006).

Wen R, Tao W, Li Y ja Sieving PA: CNTF and retina. Prog Retin Eye Res 31: 136-151 (2012).

Proteopedia Page Contributors and Editors (what is this?)

Jaakko Itkonen, Eric Martz

Retrieved from "http://52.214.119.220/wiki/index.php/User:Jaakko_Itkonen"
Personal tools