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<StructureSection load='3egn' size='350' side='right' caption='Crystal structure of the human U11/U12-65K protein (PDB ID: [[3egn]]).' scene='57/579709/3egn/4'> | <StructureSection load='3egn' size='350' side='right' caption='Crystal structure of the human U11/U12-65K protein (PDB ID: [[3egn]]).' scene='57/579709/3egn/4'> | ||
| - | '''U11/U12-65K''' is one of the proteins specific for the minor spliceosome. Most eukaryotic genomes harbor two types of spliceosomal introns, called U2-type and U12-type introns, which are excised by two different spliceosomes. U12-type introns are rare, and only present a small fraction of introns in any given eukaryotic genome. The U12-dependent spliceosome, also called the minor spliceosome, is responsible for the removal of these rare introns. Both spliceosomes consist of five small nuclear ribonucleoprotein particles (snRNPs), which are U1, U2, U4, U5 and U6 for the U2-dependent spliceosome and U11, U12, U4atac, U5 and U6atac for the U12-dependent spliceosome. The protein composition of the two spliceosomes is similar, and so far only seven proteins specific for the minor spliceosome have been identified<ref>PMID:10373121</ref><ref>PMID:11971955</ref><ref name="will_etal_2004">PMID:15146077</ref>. All seven proteins (called 65K, 59K, 48K, 35K, 31K, 25K and 20K) are components of the U11/U12 di-snRNP<ref name="will_etal_2004" /> that | + | '''U11/U12-65K''' is one of the proteins specific for the minor spliceosome. Most eukaryotic genomes harbor two types of spliceosomal introns, called U2-type and U12-type introns, which are excised by two different spliceosomes. U12-type introns are rare, and only present a small fraction of introns in any given eukaryotic genome. The U12-dependent spliceosome, also called the minor spliceosome, is responsible for the removal of these rare introns. Both spliceosomes consist of five small nuclear ribonucleoprotein particles (snRNPs), which are U1, U2, U4, U5 and U6 for the U2-dependent spliceosome and U11, U12, U4atac, U5 and U6atac for the U12-dependent spliceosome. The protein composition of the two spliceosomes is similar, and so far only seven proteins specific for the minor spliceosome have been identified<ref>PMID:10373121</ref><ref>PMID:11971955</ref><ref name="will_etal_2004">PMID:15146077</ref>. All seven proteins (called 65K, 59K, 48K, 35K, 31K, 25K and 20K) are components of the U11/U12 di-snRNP<ref name="will_etal_2004" /> that is responsible for the initial recognition of the U12-type and bridges the 5' and 3' ends of the intron. |
==Crystal structure of human U11/U12-65K== | ==Crystal structure of human U11/U12-65K== | ||
| - | <ref>PMID: 19447915</ref> | + | The crystal structure of the C-terminal RNA recognition motif (RRM) of human U11/U12-65K has been determined<ref>PMID: 19447915</ref> |
==Disease association== | ==Disease association== | ||
Revision as of 10:02, 9 May 2014
| This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947. |
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