4l8w
From Proteopedia
(Difference between revisions)
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<StructureSection load='4l8w' size='340' side='right' caption='[[4l8w]], [[Resolution|resolution]] 2.39Å' scene=''> | <StructureSection load='4l8w' size='340' side='right' caption='[[4l8w]], [[Resolution|resolution]] 2.39Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4l8w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8W OCA]. <br> | + | <table><tr><td colspan='2'>[[4l8w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8W FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l7q|4l7q]], [[4l8f|4l8f]], [[4l8y|4l8y]], [[4l95|4l95]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l7q|4l7q]], [[4l8f|4l8f]], [[4l8y|4l8y]], [[4l95|4l95]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Gamma-glutamyl_hydrolase Gamma-glutamyl hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.9 3.4.19.9] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8w RCSB], [http://www.ebi.ac.uk/pdbsum/4l8w PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8w RCSB], [http://www.ebi.ac.uk/pdbsum/4l8w PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase.,Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF, Chen CJ J Med Chem. 2013 Oct 10;56(19):7625-35. doi: 10.1021/jm401013e. Epub 2013 Sep 27. PMID:24028568<ref>PMID:24028568</ref> | Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase.,Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF, Chen CJ J Med Chem. 2013 Oct 10;56(19):7625-35. doi: 10.1021/jm401013e. Epub 2013 Sep 27. PMID:24028568<ref>PMID:24028568</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Gamma-glutamyl hydrolase]] | [[Category: Gamma-glutamyl hydrolase]] | ||
| - | [[Category: Chen, C J | + | [[Category: Chen, C J]] |
| - | [[Category: Chuankhayan, P | + | [[Category: Chuankhayan, P]] |
| - | [[Category: Fu, T F | + | [[Category: Fu, T F]] |
| - | [[Category: Kao, T T | + | [[Category: Kao, T T]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Sandwiched-like domain]] | [[Category: Sandwiched-like domain]] | ||
Revision as of 09:24, 5 January 2015
Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate
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