4ogq
From Proteopedia
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<StructureSection load='4ogq' size='340' side='right' caption='[[4ogq]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4ogq' size='340' side='right' caption='[[4ogq]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ogq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_sp. Nostoc sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OGQ OCA]. <br> | + | <table><tr><td colspan='2'>[[4ogq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_sp. Nostoc sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OGQ FirstGlance]. <br> |
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1O2:(2S)-3-(ALPHA-D-GALACTOPYRANOSYLOXY)-2-(HEXADECANOYLOXY)PROPYL+(9Z)-OCTADEC-9-ENOATE'>1O2</scene>, <scene name='pdbligand=2WA:(1S,8E)-1-{[(2S)-1-HYDROXY-3-{[(1S)-1-HYDROXYPENTADECYL]OXY}PROPAN-2-YL]OXY}HEPTADEC-8-EN-1-OL'>2WA</scene>, <scene name='pdbligand=2WD:(1R)-1-{[(2S)-3-HYDROXY-2-{[(1R)-1-HYDROXYPENTYL]OXY}PROPYL]OXY}HEXAN-1-OL'>2WD</scene>, <scene name='pdbligand=2WM:(1S,8E)-1-{[(2S)-3-HYDROXY-2-{[(1S)-1-HYDROXYOCTADECYL]OXY}PROPYL]OXY}OCTADEC-8-EN-1-OL'>2WM</scene>, <scene name='pdbligand=3WM:(1S,8E,1R,8Z)-1,1-{[(2S)-3-HYDROXYPROPANE-1,2-DIYL]BIS(OXY)}BISOCTADEC-8-EN-1-OL'>3WM</scene>, <scene name='pdbligand=7PH:(1R)-2-(DODECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+TETRADECANOATE'>7PH</scene>, <scene name='pdbligand=8K6:OCTADECANE'>8K6</scene>, <scene name='pdbligand=BCR:BETA-CAROTENE'>BCR</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CLA:CHLOROPHYLL+A'>CLA</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=OPC:(7R,17E)-4-HYDROXY-N,N,N,7-TETRAMETHYL-7-[(8E)-OCTADEC-8-ENOYLOXY]-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-17-EN-1-AMINIUM+4-OXIDE'>OPC</scene>, <scene name='pdbligand=SQD:1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL'>SQD</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene><br> | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1O2:(2S)-3-(ALPHA-D-GALACTOPYRANOSYLOXY)-2-(HEXADECANOYLOXY)PROPYL+(9Z)-OCTADEC-9-ENOATE'>1O2</scene>, <scene name='pdbligand=2WA:(1S,8E)-1-{[(2S)-1-HYDROXY-3-{[(1S)-1-HYDROXYPENTADECYL]OXY}PROPAN-2-YL]OXY}HEPTADEC-8-EN-1-OL'>2WA</scene>, <scene name='pdbligand=2WD:(1R)-1-{[(2S)-3-HYDROXY-2-{[(1R)-1-HYDROXYPENTYL]OXY}PROPYL]OXY}HEXAN-1-OL'>2WD</scene>, <scene name='pdbligand=2WM:(1S,8E)-1-{[(2S)-3-HYDROXY-2-{[(1S)-1-HYDROXYOCTADECYL]OXY}PROPYL]OXY}OCTADEC-8-EN-1-OL'>2WM</scene>, <scene name='pdbligand=3WM:(1S,8E,1R,8Z)-1,1-{[(2S)-3-HYDROXYPROPANE-1,2-DIYL]BIS(OXY)}BISOCTADEC-8-EN-1-OL'>3WM</scene>, <scene name='pdbligand=7PH:(1R)-2-(DODECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+TETRADECANOATE'>7PH</scene>, <scene name='pdbligand=8K6:OCTADECANE'>8K6</scene>, <scene name='pdbligand=BCR:BETA-CAROTENE'>BCR</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CLA:CHLOROPHYLL+A'>CLA</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=OPC:(7R,17E)-4-HYDROXY-N,N,N,7-TETRAMETHYL-7-[(8E)-OCTADEC-8-ENOYLOXY]-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-17-EN-1-AMINIUM+4-OXIDE'>OPC</scene>, <scene name='pdbligand=SQD:1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL'>SQD</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene><br> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vf5|1vf5]], [[1q90|1q90]], [[2e74|2e74]], [[2e75|2e75]], [[2e76|2e76]], [[2zt9|2zt9]], [[4h44|4h44]], [[4h13|4h13]], [[4h0l|4h0l]], [[3cx5|3cx5]]</td></tr> | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vf5|1vf5]], [[1q90|1q90]], [[2e74|2e74]], [[2e75|2e75]], [[2e76|2e76]], [[2zt9|2zt9]], [[4h44|4h44]], [[4h13|4h13]], [[4h0l|4h0l]], [[3cx5|3cx5]]</td></tr> | ||
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plastoquinol--plastocyanin_reductase Plastoquinol--plastocyanin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.9.1 1.10.9.1] </span></td></tr> |
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ogq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ogq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ogq RCSB], [http://www.ebi.ac.uk/pdbsum/4ogq PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ogq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ogq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ogq RCSB], [http://www.ebi.ac.uk/pdbsum/4ogq PDBsum]</span></td></tr> | ||
<table> | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The role of lipids in the assembly, structure, and function of hetero-oligomeric membrane protein complexes is poorly understood. The dimeric photosynthetic cytochrome b6f complex, a 16-mer of eight distinct subunits and 26 transmembrane helices, catalyzes transmembrane proton-coupled electron transfer for energy storage. Using a 2.5 A crystal structure of the dimeric complex, we identified 23 distinct lipid-binding sites per monomer. Annular lipids are proposed to provide a connection for super-complex formation with the photosystem-I reaction center and the LHCII kinase enzyme for transmembrane signaling. Internal lipids mediate crosslinking to stabilize the domain-swapped iron-sulfur protein subunit, dielectric heterogeneity within intermonomer and intramonomer electron transfer pathways, and dimer stabilization through lipid-mediated intermonomer interactions. This study provides a complete structure analysis of lipid-mediated functions in a multi-subunit membrane protein complex and reveals lipid sites at positions essential for assembly and function. | ||
| + | |||
| + | Internal Lipid Architecture of the Hetero-Oligomeric Cytochrome b6f Complex.,Hasan SS, Cramer WA Structure. 2014 Jul 8;22(7):1008-15. doi: 10.1016/j.str.2014.05.004. Epub 2014, Jun 12. PMID:24931468<ref>PMID:24931468</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:33, 23 July 2014
Internal Lipid Architecture of the Hetero-Oligomeric Cytochrome b6f Complex
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