2yal
From Proteopedia
(Difference between revisions)
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<StructureSection load='2yal' size='340' side='right' caption='[[2yal]], [[Resolution|resolution]] 2.27Å' scene=''> | <StructureSection load='2yal' size='340' side='right' caption='[[2yal]], [[Resolution|resolution]] 2.27Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yal]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAL OCA]. <br> | + | <table><tr><td colspan='2'>[[2yal]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YAL FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b0n|1b0n]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b0n|1b0n]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yal OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yal RCSB], [http://www.ebi.ac.uk/pdbsum/2yal PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU]] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structure and Organisation of SinR, the Master Regulator of Biofilm Formation in Bacillus subtilis.,Colledge VL, Fogg MJ, Levdikov VM, Leech A, Dodson EJ, Wilkinson AJ J Mol Biol. 2011 Aug 19;411(3):597-613. Epub 2011 Jun 25. PMID:21708175<ref>PMID:21708175</ref> | Structure and Organisation of SinR, the Master Regulator of Biofilm Formation in Bacillus subtilis.,Colledge VL, Fogg MJ, Levdikov VM, Leech A, Dodson EJ, Wilkinson AJ J Mol Biol. 2011 Aug 19;411(3):597-613. Epub 2011 Jun 25. PMID:21708175<ref>PMID:21708175</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
| - | [[Category: Colledge, V L | + | [[Category: Colledge, V L]] |
| - | [[Category: Dodson, E J | + | [[Category: Dodson, E J]] |
| - | [[Category: Fogg, M J | + | [[Category: Fogg, M J]] |
| - | [[Category: Leech, A | + | [[Category: Leech, A]] |
| - | [[Category: Levdikov, V M | + | [[Category: Levdikov, V M]] |
| - | [[Category: Wilkinson, A J | + | [[Category: Wilkinson, A J]] |
[[Category: Antagonist]] | [[Category: Antagonist]] | ||
[[Category: Sporulation]] | [[Category: Sporulation]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulator]] | [[Category: Transcription regulator]] | ||
Revision as of 23:00, 24 December 2014
SINR, MASTER REGULATOR OF BIOFILM FORMATION IN BACILLUS SUBTILIS
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