2xpb

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<StructureSection load='2xpb' size='340' side='right' caption='[[2xpb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2xpb' size='340' side='right' caption='[[2xpb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPB OCA]. <br>
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<table><tr><td colspan='2'>[[2xpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XPB FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=4GE:5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC+ACID'>4GE</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=4GE:5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC+ACID'>4GE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f8a|1f8a]], [[1i8g|1i8g]], [[1pin|1pin]], [[2xp3|2xp3]], [[2xp8|2xp8]], [[2xp5|2xp5]], [[1nmv|1nmv]], [[2xp9|2xp9]], [[1nmw|1nmw]], [[1zcn|1zcn]], [[2xp4|2xp4]], [[2xp7|2xp7]], [[2f21|2f21]], [[2xp6|2xp6]], [[1i8h|1i8h]], [[2xpa|2xpa]], [[1i6c|1i6c]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f8a|1f8a]], [[1i8g|1i8g]], [[1pin|1pin]], [[2xp3|2xp3]], [[2xp8|2xp8]], [[2xp5|2xp5]], [[1nmv|1nmv]], [[2xp9|2xp9]], [[1nmw|1nmw]], [[1zcn|1zcn]], [[2xp4|2xp4]], [[2xp7|2xp7]], [[2f21|2f21]], [[2xp6|2xp6]], [[1i8h|1i8h]], [[2xpa|2xpa]], [[1i6c|1i6c]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpb RCSB], [http://www.ebi.ac.uk/pdbsum/2xpb PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpb RCSB], [http://www.ebi.ac.uk/pdbsum/2xpb PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.,Potter A, Oldfield V, Nunns C, Fromont C, Ray S, Northfield CJ, Bryant CJ, Scrace SF, Robinson D, Matossova N, Baker L, Dokurno P, Surgenor AE, Davis B, Richardson CM, Murray JB, Moore JD Bioorg Med Chem Lett. 2010 Nov 15;20(22):6483-8. Epub 2010 Sep 17. PMID:20932746<ref>PMID:20932746</ref>
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.,Potter A, Oldfield V, Nunns C, Fromont C, Ray S, Northfield CJ, Bryant CJ, Scrace SF, Robinson D, Matossova N, Baker L, Dokurno P, Surgenor AE, Davis B, Richardson CM, Murray JB, Moore JD Bioorg Med Chem Lett. 2010 Nov 15;20(22):6483-8. Epub 2010 Sep 17. PMID:20932746<ref>PMID:20932746</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
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[[Category: Baker, L.]]
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[[Category: Baker, L]]
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[[Category: Bryant, C J.]]
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[[Category: Bryant, C J]]
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[[Category: Davis, B E.]]
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[[Category: Davis, B E]]
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[[Category: Dokurno, P.]]
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[[Category: Dokurno, P]]
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[[Category: Fromont, C.]]
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[[Category: Fromont, C]]
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[[Category: Matossova, N.]]
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[[Category: Matossova, N]]
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[[Category: Moore, J D.]]
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[[Category: Moore, J D]]
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[[Category: Murray, J B.]]
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[[Category: Murray, J B]]
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[[Category: Northfield, C J.]]
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[[Category: Northfield, C J]]
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[[Category: Nunns, C.]]
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[[Category: Nunns, C]]
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[[Category: Oldfield, V.]]
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[[Category: Oldfield, V]]
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[[Category: Potter, A.]]
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[[Category: Potter, A]]
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[[Category: Ray, S.]]
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[[Category: Ray, S]]
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[[Category: Richardson, C M.]]
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[[Category: Richardson, C M]]
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[[Category: Robinson, D.]]
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[[Category: Robinson, D]]
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[[Category: Scrace, S F.]]
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[[Category: Scrace, S F]]
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[[Category: Surgenor, A E.]]
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[[Category: Surgenor, A E]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Oncogenic transformation]]
[[Category: Oncogenic transformation]]
[[Category: Proline directed kinase]]
[[Category: Proline directed kinase]]

Revision as of 13:58, 24 December 2014

DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION

2xpb, resolution 2.00Å

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