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2xqn
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution|resolution]] 2.62Å' scene=''> | <StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution|resolution]] 2.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. <br> | + | <table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2iyb|2iyb]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2iyb|2iyb]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [http://www.ebi.ac.uk/pdbsum/2xqn PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TES_HUMAN TES_HUMAN]] Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.<ref>PMID:11420696</ref> <ref>PMID:12695497</ref> <ref>PMID:12571287</ref> [[http://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.,Boeda B, Knowles PP, Briggs D, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M J Biol Chem. 2011 Jan 29. PMID:21278383<ref>PMID:21278383</ref> | Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.,Boeda B, Knowles PP, Briggs D, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M J Biol Chem. 2011 Jan 29. PMID:21278383<ref>PMID:21278383</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 21: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Briggs, D C | + | [[Category: Briggs, D C]] |
| - | [[Category: Knowles, P P | + | [[Category: Knowles, P P]] |
| - | [[Category: Mcdonald, N Q | + | [[Category: Mcdonald, N Q]] |
| - | [[Category: Murray-Rust, J | + | [[Category: Murray-Rust, J]] |
[[Category: Acrosome]] | [[Category: Acrosome]] | ||
[[Category: Cytoskeleton]] | [[Category: Cytoskeleton]] | ||
[[Category: Focal adhesion]] | [[Category: Focal adhesion]] | ||
[[Category: Metal-binding protein]] | [[Category: Metal-binding protein]] | ||
Revision as of 20:48, 25 December 2014
COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF TES WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A
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