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2ygy
From Proteopedia
(Difference between revisions)
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<StructureSection load='2ygy' size='340' side='right' caption='[[2ygy]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2ygy' size='340' side='right' caption='[[2ygy]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ygy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGY OCA]. <br> | + | <table><tr><td colspan='2'>[[2ygy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YGY FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ygz|2ygz]], [[2wnq|2wnq]], [[2wkj|2wkj]], [[1fdz|1fdz]], [[1fdy|1fdy]], [[2wpb|2wpb]], [[2wo5|2wo5]], [[2wnn|2wnn]], [[1nal|1nal]], [[1hl2|1hl2]], [[2xfw|2xfw]], [[2wnz|2wnz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ygz|2ygz]], [[2wnq|2wnq]], [[2wkj|2wkj]], [[1fdz|1fdz]], [[1fdy|1fdy]], [[2wpb|2wpb]], [[2wo5|2wo5]], [[2wnn|2wnn]], [[1nal|1nal]], [[1hl2|1hl2]], [[2xfw|2xfw]], [[2wnz|2wnz]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ygy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ygy RCSB], [http://www.ebi.ac.uk/pdbsum/2ygy PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ygy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ygy RCSB], [http://www.ebi.ac.uk/pdbsum/2ygy PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: N-acetylneuraminate lyase]] | [[Category: N-acetylneuraminate lyase]] | ||
| - | [[Category: Berry, A | + | [[Category: Berry, A]] |
| - | [[Category: Campeotto, I | + | [[Category: Campeotto, I]] |
| - | [[Category: Nelson, A | + | [[Category: Nelson, A]] |
| - | [[Category: Pearson, A R | + | [[Category: Pearson, A R]] |
| - | [[Category: Phillips, S E.V | + | [[Category: Phillips, S E.V]] |
[[Category: Directed evolution]] | [[Category: Directed evolution]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Protein engineering]] | [[Category: Protein engineering]] | ||
[[Category: Substrate specificity]] | [[Category: Substrate specificity]] | ||
Revision as of 20:12, 25 December 2014
Structure of wild type E. coli N-acetylneuraminic acid lyase in space group P21 crystal form II
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