This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Sandbox Reserved 932

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 27: Line 27:
=== Denmotoxin interacts with acetylcholine-receptors ===
=== Denmotoxin interacts with acetylcholine-receptors ===
-
Biochemistry of denmotoxin is unique for its specifity to bird nicotinic acetyl choline receptors. Binding of denmotoxin to a chick muscle AcHR (a1ByS) is a highly irreversible when interaction with identical subunit assembly in mouse AcHR was reversible. Here a picture of the complex where the toxin is bound to the AChR. The active sites which interact with the receptor.
+
Biochemistry of denmotoxin is unique for its specifity to bird nicotinic acetyl choline receptors (nAChR). Binding of denmotoxin to a chick muscle AChR (a1ByS) is a highly irreversible when interaction with identical subunit assembly in mouse AChR was reversible. Here a picture of the complex where the toxin is bound to the AChR. The active sites which interact with the receptor.
===Active site organisation===
===Active site organisation===

Revision as of 12:32, 14 May 2014

This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing


B. Dendrophila monomeric toxin (Denmotoxin) is the primary protein of snake venom used by Boiga dendrophila. This colubrid snake lives in Southest Asian lowland rainforest and mangrove swamps using birds as its primary prey.

One of the most well characterized snake venom protein families is the Three-finger-toxins (3FTX). These proteins have three β-stranded finger-like loops, stabilized by four disulphide bridges on the surface of a globular core. In non-convential 3TFXs a fifth disulphide bridge can be present as is the case in Denmotoxin.

How the overall structure looks like? Subunits orientation, chains: the number and relative positions, etc.

Denmotoxin

Structure of denmotoxin (PDB entry 2H5F)

Drag the structure with the mouse to rotate

Additional Information

References

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_932"
Personal tools