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== Introduction ==
== Introduction ==
[[Image:Organ_identity.jpg|400px|left|thumb| Schematic presentation LEAFY regulatory roles (A) and the ABC model controlling floral organ identity (B). ]]
[[Image:Organ_identity.jpg|400px|left|thumb| Schematic presentation LEAFY regulatory roles (A) and the ABC model controlling floral organ identity (B). ]]
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'''''FLORICAULA/LEAFY''''' ('''''FLO/LFY''''') genes encode a plant specific transcription factor family that controlling floral meristem/organ identity. In the plant model system ''Arabidopsis thaliana '', LFY acts upstream of
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'''''FLORICAULA/LEAFY''''' ('''''FLO/LFY''''') genes encode a plant specific transcription factor family that controlling floral meristem identity. (1) In the plant model system ''Arabidopsis thaliana '', ‘’LFY’’ also acts upstream of floral homeotic genes to modulate organ identity. LFY activates the organ identity genes by binding to promoter regions of floral organ identity genes. LFY can directly bind to the promoter to ‘’’’’APELATA1’’’’’ (‘’’’’AP1’’’’’), while co-regulators ‘’’’’UNUSUAL FLORAL ORGANS’’’’’ (‘’’’’UFO’’’’’) and ‘’’’’’WUSCHEL’’’’’(‘’’’’WUS’’’’’) are required for increment of binding affinity to promoter regions of ‘’’’’APELATA3’’’’’ (‘’’’’AP3’’’’’) and ‘’’’’AGAMOUS’’’’’ (‘’’’’AG’’’’’), respectively.
== Structural Basis of LEAFY binding ==
== Structural Basis of LEAFY binding ==
<Structure load='2VY1' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
<Structure load='2VY1' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
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== Reference ==
== Reference ==
1 Weigel D, Alvarez J, Smyth DR, Yanofsky MF, Meyerowitz EM (1992). "LEAFY controls floral meristem identity in Arabidopsis". Cell 69 (5): 843–859. doi:10.1016/0092-8674(92)90295-N. PMID 1350515.
1 Weigel D, Alvarez J, Smyth DR, Yanofsky MF, Meyerowitz EM (1992). "LEAFY controls floral meristem identity in Arabidopsis". Cell 69 (5): 843–859. doi:10.1016/0092-8674(92)90295-N. PMID 1350515.
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Revision as of 04:39, 16 May 2014

This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947.
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Contents

DNA Binding Domain of LEAFY: A Master Regulator in Flower Development

Introduction

Schematic presentation LEAFY regulatory roles (A) and the ABC model controlling floral organ identity (B).
Schematic presentation LEAFY regulatory roles (A) and the ABC model controlling floral organ identity (B).

FLORICAULA/LEAFY (FLO/LFY) genes encode a plant specific transcription factor family that controlling floral meristem identity. (1) In the plant model system Arabidopsis thaliana , ‘’LFY’’ also acts upstream of floral homeotic genes to modulate organ identity. LFY activates the organ identity genes by binding to promoter regions of floral organ identity genes. LFY can directly bind to the promoter to ‘’’’’APELATA1’’’’’ (‘’’’’AP1’’’’’), while co-regulators ‘’’’’UNUSUAL FLORAL ORGANS’’’’’ (‘’’’’UFO’’’’’) and ‘’’’’’WUSCHEL’’’’’(‘’’’’WUS’’’’’) are required for increment of binding affinity to promoter regions of ‘’’’’APELATA3’’’’’ (‘’’’’AP3’’’’’) and ‘’’’’AGAMOUS’’’’’ (‘’’’’AG’’’’’), respectively.

Structural Basis of LEAFY binding

Insert caption here

Drag the structure with the mouse to rotate

General information about the structure

DNA recognition is conducted by a HTH-like motif

DNA binding required cooperative dimerization

LEAFY Evolution

Reference

1 Weigel D, Alvarez J, Smyth DR, Yanofsky MF, Meyerowitz EM (1992). "LEAFY controls floral meristem identity in Arabidopsis". Cell 69 (5): 843–859. doi:10.1016/0092-8674(92)90295-N. PMID 1350515. 2

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