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| - | ==Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase==
| + | #REDIRECT [[4qag]] This PDB entry is obsolete and replaced by 4qag |
| - | <StructureSection load='4je2' size='340' side='right' caption='[[4je2]], [[Resolution|resolution]] 1.65Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4je2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JE2 FirstGlance]. <br>
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| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F95:(7,8-DIHYDROXY-2-OXO-2H-CHROMEN-4-YL)ACETIC+ACID'>F95</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
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| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k2p|3k2p]], [[3ig1|3ig1]], [[3qlh|3qlh]], [[3ifj|3ifj]], [[2zd1|2zd1]]</td></tr>
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| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11678 HIV-1])</td></tr>
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| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exoribonuclease_H Exoribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.2 3.1.13.2] </span></td></tr>
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| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4je2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4je2 RCSB], [http://www.ebi.ac.uk/pdbsum/4je2 PDBsum]</span></td></tr>
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| - | <table>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Exoribonuclease H]]
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| - | [[Category: Hiv-1]]
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| - | [[Category: Arnold, E.]]
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| - | [[Category: Himmel, D M.]]
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| - | [[Category: Ho, W C.]]
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| - | [[Category: Active site]]
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| - | [[Category: Aid]]
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| - | [[Category: Dihydroxy-benzopyrone derivative]]
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| - | [[Category: Dihydroxycoumarin analog]]
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| - | [[Category: Divalent cation chelator]]
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| - | [[Category: Hydrolase-hydrolase inhibitor complex]]
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| - | [[Category: Protein-inhibitor complex]]
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| - | [[Category: Reverse transcriptase]]
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| - | [[Category: Rnase h inhibitor]]
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| - | [[Category: Structure-based drug design]]
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