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1a4f
From Proteopedia
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|PDB= 1a4f |SIZE=350|CAPTION= <scene name='initialview01'>1a4f</scene>, resolution 2.0Å | |PDB= 1a4f |SIZE=350|CAPTION= <scene name='initialview01'>1a4f</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> | + | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4f OCA], [http://www.ebi.ac.uk/pdbsum/1a4f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a4f RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Gu, X.]] | [[Category: Gu, X.]] | ||
[[Category: Zhang, J.]] | [[Category: Zhang, J.]] | ||
| - | [[Category: HEM]] | ||
| - | [[Category: OXY]] | ||
[[Category: erythrocyte]] | [[Category: erythrocyte]] | ||
[[Category: heme]] | [[Category: heme]] | ||
| Line 31: | Line 32: | ||
[[Category: respiratory protein]] | [[Category: respiratory protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:32:59 2008'' |
Revision as of 15:33, 30 March 2008
| |||||||
| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)
Overview
We have determined the crystal structure of bar-headed goose haemoglobin in the oxy form to a resolution of 2.0 A. The R-factor of the model is 19.8%. The structure is similar to human HbA, but contacts between the subunits show slightly altered packing of the tetramer. Bar-headed goose blood shows a greatly elevated oxygen affinity compared to closely related species of geese. This is apparently due to a single proline to alanine mutation at the alpha 1 beta 1 interface which destabilises the T state of the protein. The beta chain N and C termini are well-localized, and together with other neighbouring basic groups they form a strongly positively charged groove at the entrance to the central cavity around the molecular dyad. The well-ordered conformation and the three-dimensional distribution of positive charges clearly indicate this area to be the inositol pentaphosphate binding site of bird haemoglobins.
About this Structure
1A4F is a Protein complex structure of sequences from Anser indicus. Full crystallographic information is available from OCA.
Reference
The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:8568892
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