3po7
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3po7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PO7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3po7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PO7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZON:1-(1,2-BENZOXAZOL-3-YL)METHANESULFONAMIDE'>ZON</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZON:1-(1,2-BENZOXAZOL-3-YL)METHANESULFONAMIDE'>ZON</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAOB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAOB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3po7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3po7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3po7 RCSB], [http://www.ebi.ac.uk/pdbsum/3po7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3po7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3po7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3po7 RCSB], [http://www.ebi.ac.uk/pdbsum/3po7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 16: | ||
Interactions of Monoamine Oxidases with the Antiepileptic Drug Zonisamide: Specificity of Inhibition and Structure of the Human Monoamine Oxidase B Complex.,Binda C, Aldeco M, Mattevi A, Edmondson DE J Med Chem. 2010 Dec 22. PMID:21175212<ref>PMID:21175212</ref> | Interactions of Monoamine Oxidases with the Antiepileptic Drug Zonisamide: Specificity of Inhibition and Structure of the Human Monoamine Oxidase B Complex.,Binda C, Aldeco M, Mattevi A, Edmondson DE J Med Chem. 2010 Dec 22. PMID:21175212<ref>PMID:21175212</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Monoamine oxidase|Monoamine oxidase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 22: | Line 27: | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Monoamine oxidase]] | [[Category: Monoamine oxidase]] | ||
| - | [[Category: Aldeco, M | + | [[Category: Aldeco, M]] |
| - | [[Category: Binda, C | + | [[Category: Binda, C]] |
| - | [[Category: Edmondson, D E | + | [[Category: Edmondson, D E]] |
| - | [[Category: Mattevi, A | + | [[Category: Mattevi, A]] |
[[Category: Antiparkinson drug]] | [[Category: Antiparkinson drug]] | ||
[[Category: Fad]] | [[Category: Fad]] | ||
Revision as of 17:43, 24 December 2014
Human monoamine oxidase B in complex with zonisamide
| |||||||||||
