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4chb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4chb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHB FirstGlance]. <br> | <table><tr><td colspan='2'>[[4chb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ch9|4ch9]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ch9|4ch9]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chb RCSB], [http://www.ebi.ac.uk/pdbsum/4chb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chb RCSB], [http://www.ebi.ac.uk/pdbsum/4chb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/WNK4_HUMAN WNK4_HUMAN]] Defects in WNK4 are a cause of pseudohypoaldosteronism type 2B (PHA2B) [MIM:[http://omim.org/entry/614491 614491]]. PHAII is an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.<ref>PMID:11498583</ref> | [[http://www.uniprot.org/uniprot/WNK4_HUMAN WNK4_HUMAN]] Defects in WNK4 are a cause of pseudohypoaldosteronism type 2B (PHA2B) [MIM:[http://omim.org/entry/614491 614491]]. PHAII is an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.<ref>PMID:11498583</ref> | ||
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Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.,Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T Biochem J. 2014 Jun 1;460(2):237-46. doi: 10.1042/BJ20140153. PMID:24641320<ref>PMID:24641320</ref> | Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.,Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T Biochem J. 2014 Jun 1;460(2):237-46. doi: 10.1042/BJ20140153. PMID:24641320<ref>PMID:24641320</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| - | [[Category: Alessi, D R | + | [[Category: Alessi, D R]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Bullock, A | + | [[Category: Bullock, A]] |
| - | [[Category: Canning, P | + | [[Category: Canning, P]] |
| - | [[Category: Cooper, C D.O | + | [[Category: Cooper, C D.O]] |
| - | [[Category: Delft, F Von | + | [[Category: Delft, F Von]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Kopec, J | + | [[Category: Kopec, J]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Kurz, T | + | [[Category: Kurz, T]] |
| - | [[Category: Newman, J | + | [[Category: Newman, J]] |
| - | [[Category: Schumacher, F R | + | [[Category: Schumacher, F R]] |
| - | [[Category: Sorrell, F J | + | [[Category: Sorrell, F J]] |
| - | [[Category: Williams, E | + | [[Category: Williams, E]] |
[[Category: Adaptor protein]] | [[Category: Adaptor protein]] | ||
[[Category: Kelch repeat]] | [[Category: Kelch repeat]] | ||
Revision as of 14:05, 4 January 2015
Crystal structure of the human KLHL2 Kelch domain in complex with a WNK4 peptide
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Categories: Human | Non-specific serine/threonine protein kinase | Alessi, D R | Arrowsmith, C H | Bountra, C | Bullock, A | Canning, P | Cooper, C D.O | Delft, F Von | Edwards, A M | Kopec, J | Krojer, T | Kurz, T | Newman, J | Schumacher, F R | Sorrell, F J | Williams, E | Adaptor protein | Kelch repeat | Klhl3 | Protein-binding | Signaling protein-transferase complex | Ubiquitin | Wnk signalling pathway
