1a7h
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= CRYGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]) | |GENE= CRYGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7h OCA], [http://www.ebi.ac.uk/pdbsum/1a7h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a7h RCSB]</span> | ||
}} | }} | ||
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[[Category: multigene family]] | [[Category: multigene family]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:53 2008'' |
Revision as of 15:34, 30 March 2008
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| , resolution 2.56Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | CRYGS (Bos taurus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
GAMMA S CRYSTALLIN C-TERMINAL DOMAIN
Overview
The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
About this Structure
1A7H is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:9681865
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