4ou8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ou8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Syny3 Syny3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OU8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ou8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Syny3 Syny3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OU8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ou9|4ou9]], [[2biw|2biw]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ou9|4ou9]], [[2biw|2biw]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">diox1, sll1541 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111708 SYNY3])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">diox1, sll1541 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111708 SYNY3])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/All-trans-8'-apo-beta-carotenal_15,15'-oxygenase All-trans-8'-apo-beta-carotenal 15,15'-oxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.75 1.13.11.75] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/All-trans-8'-apo-beta-carotenal_15,15'-oxygenase All-trans-8'-apo-beta-carotenal 15,15'-oxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.75 1.13.11.75] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ou8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ou8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ou8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ou8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ou8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ou8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ou8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ou8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACOX_SYNY3 ACOX_SYNY3]] Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta-carotene or lycopene. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO).,Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, Von Lintig J, Palczewski K J Biol Chem. 2014 Mar 19. PMID:24648526<ref>PMID:24648526</ref> | Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO).,Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, Von Lintig J, Palczewski K J Biol Chem. 2014 Mar 19. PMID:24648526<ref>PMID:24648526</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: All-trans-8'-apo-beta-carotenal 15,15'-oxygenase]] | [[Category: All-trans-8'-apo-beta-carotenal 15,15'-oxygenase]] | ||
[[Category: Syny3]] | [[Category: Syny3]] | ||
| - | [[Category: Kiser, P D | + | [[Category: Kiser, P D]] |
| - | [[Category: Palczewski, K | + | [[Category: Palczewski, K]] |
| - | [[Category: Shi, W | + | [[Category: Shi, W]] |
| - | [[Category: Sui, X | + | [[Category: Sui, X]] |
[[Category: 4-his iron center]] | [[Category: 4-his iron center]] | ||
[[Category: Beta propeller]] | [[Category: Beta propeller]] | ||
Revision as of 15:13, 25 December 2014
Crystal structure of apocarotenoid oxygenase in the presence of C8E6
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