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4cml
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cml]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CML FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cml]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CML FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52N:1,2-DIOCTANOYL+PHOSPHATIDYL+EPI-INOSITOL+(3,4)-BISPHOSPHATE'>52N</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52N:1,2-DIOCTANOYL+PHOSPHATIDYL+EPI-INOSITOL+(3,4)-BISPHOSPHATE'>52N</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cmn|4cmn]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cmn|4cmn]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cml RCSB], [http://www.ebi.ac.uk/pdbsum/4cml PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cml RCSB], [http://www.ebi.ac.uk/pdbsum/4cml PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.,Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254<ref>PMID:24704254</ref> | Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.,Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254<ref>PMID:24704254</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 22: | Line 24: | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Phosphoinositide 5-phosphatase]] | [[Category: Phosphoinositide 5-phosphatase]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Berglund, H | + | [[Category: Berglund, H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Ekblad, T | + | [[Category: Ekblad, T]] |
| - | [[Category: Flodin, S | + | [[Category: Flodin, S]] |
| - | [[Category: Graslund, S | + | [[Category: Graslund, S]] |
| - | [[Category: Karlberg, T | + | [[Category: Karlberg, T]] |
| - | [[Category: Moche, M | + | [[Category: Moche, M]] |
| - | [[Category: Nordlund, P | + | [[Category: Nordlund, P]] |
| - | [[Category: Nyman, T | + | [[Category: Nyman, T]] |
| - | [[Category: Schuler, H | + | [[Category: Schuler, H]] |
| - | [[Category: Silvander, C | + | [[Category: Silvander, C]] |
| - | [[Category: Thorsell, A G | + | [[Category: Thorsell, A G]] |
| - | [[Category: Tresaugues, L | + | [[Category: Tresaugues, L]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
| - | [[Category: Welin, M | + | [[Category: Welin, M]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Magnesium binding]] | [[Category: Magnesium binding]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Signalling]] | [[Category: Signalling]] | ||
| - | [[Category: Structural | + | [[Category: Structural genomic]] |
Revision as of 10:44, 25 December 2014
Crystal Structure of INPP5B in complex with Phosphatidylinositol 3,4- bisphosphate
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Categories: Human | Phosphoinositide 5-phosphatase | Arrowsmith, C H | Berglund, H | Bountra, C | Edwards, A M | Ekblad, T | Flodin, S | Graslund, S | Karlberg, T | Moche, M | Nordlund, P | Nyman, T | Schuler, H | Silvander, C | Thorsell, A G | Tresaugues, L | Weigelt, J | Welin, M | Hydrolase | Magnesium binding | Sgc | Signalling | Structural genomic
