1a7x
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
|PDB= 1a7x |SIZE=350|CAPTION= <scene name='initialview01'>1a7x</scene>, resolution 2.0Å | |PDB= 1a7x |SIZE=350|CAPTION= <scene name='initialview01'>1a7x</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=FKA:BENZYL-CARBAMIC ACID [8-DEETHYL-ASCOMYCIN-8-YL]ETHYL ESTER'>FKA</scene> | + | |LIGAND= <scene name='pdbligand=FKA:BENZYL-CARBAMIC+ACID+[8-DEETHYL-ASCOMYCIN-8-YL]ETHYL+ESTER'>FKA</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7x OCA], [http://www.ebi.ac.uk/pdbsum/1a7x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a7x RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Clardy, J.]] | [[Category: Clardy, J.]] | ||
[[Category: Schultz, L W.]] | [[Category: Schultz, L W.]] | ||
| - | [[Category: FKA]] | ||
[[Category: immunophilin]] | [[Category: immunophilin]] | ||
[[Category: isomerase]] | [[Category: isomerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:10 2008'' |
Revision as of 15:35, 30 March 2008
| |||||||
| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Peptidylprolyl isomerase, with EC number 5.2.1.8 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
FKBP12-FK1012 COMPLEX
Overview
A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.
About this Structure
1A7X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618
Page seeded by OCA on Sun Mar 30 18:35:10 2008
