This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2mpc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2mpc" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Solution structure of the pyrin domain of human Pyrin==
-
 
+
<StructureSection load='2mpc' size='340' side='right' caption='[[2mpc]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
-
The entry 2mpc is ON HOLD
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2mpc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MPC FirstGlance]. <br>
-
Authors: Soh, S.L., Smith, S.J., Hill, J.M.
+
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mpc RCSB], [http://www.ebi.ac.uk/pdbsum/2mpc PDBsum]</span></td></tr>
-
 
+
<table>
-
Description: Solution structure of the pyrin domain of human Pyrin
+
== Disease ==
 +
[[http://www.uniprot.org/uniprot/MEFV_HUMAN MEFV_HUMAN]] Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF) [MIM:[http://omim.org/entry/249100 249100]]. ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence.<ref>PMID:9288758</ref> <ref>PMID:9288094</ref> <ref>PMID:11470495</ref> <ref>PMID:12384939</ref> <ref>PMID:9668175</ref> <ref>PMID:10024914</ref> <ref>PMID:10090880</ref> <ref>PMID:10364520</ref> <ref>PMID:10234504</ref> <ref>PMID:10612841</ref> <ref>PMID:10854105</ref> <ref>PMID:10842288</ref> <ref>PMID:15024744</ref> <ref>PMID:16378925</ref> <ref>PMID:16730661</ref> Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF) [MIM:[http://omim.org/entry/134610 134610]]. ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness.
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/MEFV_HUMAN MEFV_HUMAN]] Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization.<ref>PMID:10807793</ref> <ref>PMID:11468188</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Hill, J M.]]
 +
[[Category: Smith, S J.]]
 +
[[Category: Soh, S L.]]
 +
[[Category: Cs-rosetta]]
 +
[[Category: Death domain]]
 +
[[Category: Inflammation]]
 +
[[Category: Pyrin domain]]
 +
[[Category: Signaling protein]]

Revision as of 10:23, 16 July 2014

Solution structure of the pyrin domain of human Pyrin

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mpc"
Views
Personal tools
Navigation
Toolbox