4q6f
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4q6f]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6F FirstGlance]. <br> | <table><tr><td colspan='2'>[[4q6f]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6F FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6f RCSB], [http://www.ebi.ac.uk/pdbsum/4q6f PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6f RCSB], [http://www.ebi.ac.uk/pdbsum/4q6f PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Ciulli, A | + | [[Category: Ciulli, A]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Filippakopoulos, P | + | [[Category: Filippakopoulos, P]] |
| - | [[Category: Knapp, S | + | [[Category: Knapp, S]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Overvoorde, L | + | [[Category: Overvoorde, L]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Tallant, C | + | [[Category: Tallant, C]] |
[[Category: Bromodomain adjacent to zinc finger domain protein 2a]] | [[Category: Bromodomain adjacent to zinc finger domain protein 2a]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription termination factor i-interacting protein 5]] | [[Category: Transcription termination factor i-interacting protein 5]] | ||
[[Category: Ttf-i-interacting protein 5]] | [[Category: Ttf-i-interacting protein 5]] | ||
Revision as of 05:55, 25 December 2014
Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3K4 histone peptide
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Categories: Arrowsmith, C H | Bountra, C | Ciulli, A | Delft, F von | Edwards, A M | Filippakopoulos, P | Knapp, S | Krojer, T | Overvoorde, L | Structural genomic | Tallant, C | Bromodomain adjacent to zinc finger domain protein 2a | Sgc | Transcription | Transcription termination factor i-interacting protein 5 | Ttf-i-interacting protein 5
