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3ek9
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EK9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EK9 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPSB2_MOUSE SPSB2_MOUSE]] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 23: | Line 25: | ||
SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.,Kuang Z, Yao S, Xu Y, Lewis RS, Low A, Masters SL, Willson TA, Kolesnik TB, Nicholson SE, Garrett TJ, Norton RS J Mol Biol. 2009 Feb 27;386(3):662-74. Epub 2009 Jan 6. PMID:19154741<ref>PMID:19154741</ref> | SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.,Kuang Z, Yao S, Xu Y, Lewis RS, Low A, Masters SL, Willson TA, Kolesnik TB, Nicholson SE, Garrett TJ, Norton RS J Mol Biol. 2009 Feb 27;386(3):662-74. Epub 2009 Jan 6. PMID:19154741<ref>PMID:19154741</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 30: | Line 32: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Garrett, T J.P | + | [[Category: Garrett, T J.P]] |
| - | [[Category: Kuang, Z | + | [[Category: Kuang, Z]] |
| - | [[Category: Norton, R S | + | [[Category: Norton, R S]] |
| - | [[Category: Xu, Y | + | [[Category: Xu, Y]] |
| - | [[Category: Yao, S | + | [[Category: Yao, S]] |
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
[[Category: Spry domain]] | [[Category: Spry domain]] | ||
[[Category: Ubl conjugation pathway]] | [[Category: Ubl conjugation pathway]] | ||
Revision as of 10:38, 25 December 2014
SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding
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