3ld9
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ld9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ehrlichia_chaffeensis Ehrlichia chaffeensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LD9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ld9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ehrlichia_chaffeensis Ehrlichia chaffeensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LD9 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, ECH_0229 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=945 Ehrlichia chaffeensis])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, ECH_0229 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=945 Ehrlichia chaffeensis])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ld9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld9 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ld9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld9 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KTHY_EHRCR KTHY_EHRCR]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Structure of thymidylate kinase from Ehrlichia chaffeensis.,Leibly DJ, Abendroth J, Bryan CM, Sankaran B, Kelley A, Barrett LK, Stewart L, Van Voorhis WC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1090-4. Epub 2011 Aug 16. PMID:21904055<ref>PMID:21904055</ref> | Structure of thymidylate kinase from Ehrlichia chaffeensis.,Leibly DJ, Abendroth J, Bryan CM, Sankaran B, Kelley A, Barrett LK, Stewart L, Van Voorhis WC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1090-4. Epub 2011 Aug 16. PMID:21904055<ref>PMID:21904055</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Thymidylate kinase|Thymidylate kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Ehrlichia chaffeensis]] | [[Category: Ehrlichia chaffeensis]] | ||
[[Category: DTMP kinase]] | [[Category: DTMP kinase]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: Als collaborative crystallography]] | [[Category: Als collaborative crystallography]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
| - | [[Category: Ehrlichia chaffeensis]] | ||
[[Category: Emerald biostructure]] | [[Category: Emerald biostructure]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Sbri]] | [[Category: Sbri]] | ||
| - | [[Category: Seattle structural genomics center for infectious disease]] | ||
[[Category: Ssgcid]] | [[Category: Ssgcid]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Thymidylate kinase]] | [[Category: Thymidylate kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Uw]] | [[Category: Uw]] | ||
Revision as of 21:14, 25 December 2014
Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution
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