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Trypanothione reductase

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===TTR===
[[2tpr]], [[1tyt]], [[1fea]], [[1feb]], [[1fec]] – CfTTR – ''Crithidia fasciculate''<br />
[[2tpr]], [[1tyt]], [[1fea]], [[1feb]], [[1fec]] – CfTTR – ''Crithidia fasciculate''<br />
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[[2woi]] - TbTTR – ''Trypanosoma brucei''
[[2woi]] - TbTTR – ''Trypanosoma brucei''
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'''TTR binary complex'''
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===TTR binary complex===
[[1bzl]] - TcTTR + TPT<BR />
[[1bzl]] - TcTTR + TPT<BR />
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[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]] - TbTTR + inhibitor<br />
[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]] - TbTTR + inhibitor<br />
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'''TTR ternary complex'''
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===TTR ternary complex===
[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br />
[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br />

Revision as of 10:33, 28 September 2014

Template:STRUCTURE 1bzl

Trypanothione reductase (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases caused by the parasites Trypanosoma and Leishmania.

Contents

3D structures of trypanothione reductase

Updated on 28-September-2014

TTR

2tpr, 1tyt, 1fea, 1feb, 1fec – CfTTR – Crithidia fasciculate
1aog, 1nda – TcTTR – Trypanosoma cruzi
2jk6 - LiTTR – Leishmania infantum
2woi - TbTTR – Trypanosoma brucei

TTR binary complex

1bzl - TcTTR + TPT
1gxf - TcTTR + inhibitor
2wba, 2wov - TbTTR + NADPH
2wp5, 2wp6, 2wpc, 2wpe, 2wpf, 4nev - TbTTR + inhibitor

TTR ternary complex

2w0h, 2x50 - LiTTR + NADPH + metal ion
2yau - LiTTR + NADPH + inhibitor
2wow - TbTTR + NADPH + TPT
4adw - LiTTR + NADPH + TPT
4apn - LiTTR + NADPH + inhibitor

1typ – CfTTR + NADP + TPT

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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