3mcb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3mcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MCB FirstGlance]. <br> | <table><tr><td colspan='2'>[[3mcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MCB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mce|3mce]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mce|3mce]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Alpha NAC, HSD48, NACA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Beta NAC (BTF3b), BTF3, NACB, OK/SW-cl.8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Alpha NAC, HSD48, NACA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Beta NAC (BTF3b), BTF3, NACB, OK/SW-cl.8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mcb RCSB], [http://www.ebi.ac.uk/pdbsum/3mcb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mcb RCSB], [http://www.ebi.ac.uk/pdbsum/3mcb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NACA_HUMAN NACA_HUMAN]] Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<ref>PMID:9877153</ref> <ref>PMID:10982809</ref> <ref>PMID:15784678</ref> [[http://www.uniprot.org/uniprot/BTF3_HUMAN BTF3_HUMAN]] General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit.,Wang L, Zhang W, Wang L, Zhang XC, Li X, Rao Z Protein Cell. 2010 Apr;1(4):406-16. Epub 2010 May 8. PMID:21203952<ref>PMID:21203952</ref> | Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit.,Wang L, Zhang W, Wang L, Zhang XC, Li X, Rao Z Protein Cell. 2010 Apr;1(4):406-16. Epub 2010 May 8. PMID:21203952<ref>PMID:21203952</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[NAC transcription factor|NAC transcription factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Li, X M | + | [[Category: Li, X M]] |
| - | [[Category: Rao, Z | + | [[Category: Rao, Z]] |
| - | [[Category: Wang, L | + | [[Category: Wang, L]] |
| - | [[Category: Wang, L F | + | [[Category: Wang, L F]] |
| - | [[Category: Zhang, W C | + | [[Category: Zhang, W C]] |
| - | [[Category: Zhang, X J.C | + | [[Category: Zhang, X J.C]] |
[[Category: Beta-barrel like structure]] | [[Category: Beta-barrel like structure]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Heterodimer]] | [[Category: Heterodimer]] | ||
[[Category: Nac]] | [[Category: Nac]] | ||
Revision as of 09:57, 25 December 2014
Crystal structure of NAC domains of human nascent polypeptide-associated complex (NAC)
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Categories: Homo sapiens | Li, X M | Rao, Z | Wang, L | Wang, L F | Zhang, W C | Zhang, X J.C | Beta-barrel like structure | Chaperone | Heterodimer | Nac
