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3o3q
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3o3q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O3Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[3o3q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O3Q FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jqz|1jqz]], [[3o49|3o49]], [[3o4a|3o4a]], [[3o4b|3o4b]], [[3o4c|3o4c]], [[3o4d|3o4d]], [[3o4e|3o4e]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jqz|1jqz]], [[3o49|3o49]], [[3o4a|3o4a]], [[3o4b|3o4b]], [[3o4c|3o4c]], [[3o4d|3o4d]], [[3o4e|3o4e]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o3q RCSB], [http://www.ebi.ac.uk/pdbsum/3o3q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o3q RCSB], [http://www.ebi.ac.uk/pdbsum/3o3q PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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A polypeptide "building block" for the beta-trefoil fold identified by "top-down symmetric deconstruction".,Lee J, Blaber SI, Dubey VK, Blaber M J Mol Biol. 2011 Apr 15;407(5):744-63. Epub 2011 Feb 16. PMID:21315087<ref>PMID:21315087</ref> | A polypeptide "building block" for the beta-trefoil fold identified by "top-down symmetric deconstruction".,Lee J, Blaber SI, Dubey VK, Blaber M J Mol Biol. 2011 Apr 15;407(5):744-63. Epub 2011 Feb 16. PMID:21315087<ref>PMID:21315087</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Fibroblast growth factor|Fibroblast growth factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Blaber, M | + | [[Category: Blaber, M]] |
| - | [[Category: Lee, J | + | [[Category: Lee, J]] |
[[Category: Beta-trefoil]] | [[Category: Beta-trefoil]] | ||
[[Category: Heparin-binding protein]] | [[Category: Heparin-binding protein]] | ||
Revision as of 11:14, 25 December 2014
Crystal structure of "L44F/M67I/L73V/A103G/deletion 104-106/F108Y/V109L/L111I/C117V/R119G/deletion 120-122" mutant form of Human acidic fibroblast growth factor
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